| Name | brains |
|---|---|
| Synonyms | BPG dependent PGAM 1; Brain; CDABP0006; PGAM 1; PGAM B; PGAM1; PGAM1 protein; PGAMA… |
| Name | trichlorfon |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10681099 | Lesser J, Blodgett D, Ehrich M: Comparison of oxime-initiated reactivation of organophosphorous-inhibited acetylcholinesterase in brains of avian embryos. J Toxicol Environ Health A. 2000 Jan 14;59(1):57-66. Concentration-related increases in AChE activities were noted in embryo brains reactivated with 2-PAM, TMB, and HI-6. 2-PAM was the most effective reactivator of trichlorfon-inhibited AChE; 2-PAM and obidoxime were relatively similar in effectiveness for reactivation of AChE inhibited with the other OP insecticides used as test agents. |
32(0,1,1,2) | Details |
| 6733596 | Slott V, Ecobichon DJ: An acute and subacute neurotoxicity assessment of trichlorfon. . Can J Physiol Pharmacol. 1984 May;62(5):513-8. Seventy-two hours after the final dose the hens were euthanized, the brains, spinal cords, and distal sciatic nerves were removed for enzymatic and (or) histological examination. |
1(0,0,0,1) | Details |
| 15582113 | Spowart-Manning L, van der Staay FJ: Spatial discrimination deficits by excitotoxic lesions in the Morris water escape task. Behav Brain Res. 2005 Jan 30;156(2):269-76. The effects of the cholinesterase inhibitors (ChEI) metrifonate and were assessed on spatial performance of rats with bilateral lesions of the entorhinal cortex (EC), which is thought to model early changes in the brains of patients suffering from Alzheimer's disease. |
1(0,0,0,1) | Details |
| 14535624 | Rakonczay Z: Potencies and selectivities of inhibitors of acetylcholinesterase and its molecular forms in normal and Alzheimer's disease brain. Acta Biol Hung. 2003;54(2):183-9. Additionally, the IC50 values of different molecular forms of AChE (monomeric, G1, and tetrameric, G4) were determined in the cerebral cortex in both normal and Alzheimer's human brains. |
1(0,0,0,1) | Details |
| 10773217 | Pakaski M, Rakonczay Z, Fakla I, Papp H, Kasa P: In vitro effects of metrifonate on neuronal amyloid precursor protein processing and protein kinase C level. Brain Res. 2000 Apr 28;863(1-2):266-70. Alteration in the processing of the amyloid precursor protein (APP) is a central event in the formation of amyloid deposits in the brains of individuals with Alzheimer's disease (AD). |
1(0,0,0,1) | Details |
| 11099780 | Pakaski M, Rakonczay Z, Kasa P: Reversible and irreversible acetylcholinesterase inhibitors cause changes in neuronal amyloid precursor protein processing and protein kinase C level in vitro. Neurochem Int. 2001 Mar;38(3):219-26. The alternative routes of cleavage of the amyloid precursor protein (APP) result in the generation and secretion of both soluble APP and beta-amyloid, the latter being the main component of the amyloid deposits in the brains of individuals with Alzheimer's disease (AD). |
1(0,0,0,1) | Details |
| 16822217 | Dhingra D, Parle M, Kulkarni SK: Comparative brain cholinesterase-inhibiting activity of Glycyrrhiza glabra, Myristica fragrans, and metrifonate in mice. J Med Food. 2006 Summer;9(2):281-3. Acetylcholinesterase enzyme was estimated in brains of mice. |
1(0,0,0,1) | Details |