Protein Information

Name immunoglobulin (protein family or complex)
Synonyms Immunoglobulin; Immunoglobulins

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
11023194 Fujii S, Huang S, Fong TC, Ando D, Burrows F, Jolly DJ, Nemunaitis J, Hoon DS: Induction of melanoma-associated antigen systemic immunity upon intratumoral delivery of interferon-gamma retroviral vector in melanoma patients. Cancer Gene Ther. 2000 Sep;7(9):1220-30.


Patients were assessed for immunoglobulin G antibody (Ab) responses to the melanoma-associated antigens (MAA) tyrosinase, gp100, TRP-2, and MAGE-A1 by affinity enzyme-linked immunosorbent assay.
1(0,0,0,1) Details
6224998 Obukhov NV, Ametov AS, Abedrabbo Kh: [Radionuclide complex in vitro studies in the diagnosis of lung cancer] . Med Radiol. 1983 Aug;28(8):19-24.


The concentration in the blood serum of biologically active agents: CEA, PTH, immunoglobulin E, ferritin, hydrocortisone and beta2-microglobulin was determined in 76 cancer patients and 19 patients with nontumorous lung diseases.
1(0,0,0,1) Details
1373670 Temponi M, Gold AM, Ferrone S: Binding parameters and idiotypic profile of the whole immunoglobulin and Fab' fragments of murine monoclonal antibody to distinct determinants of the human high molecular weight-melanoma associated antigen. Cancer Res. 1992 May 1;52(9):2497-503.

1(0,0,0,1) Details
19134253 Qiao XH, Xie XT, Jiang SY, Shi W, Li W, Zhou JJ: [Natural history of moderate aplastic anemia in children and effects of immunosuppressive therapy]. Zhonghua Er Ke Za Zhi. 2008 Dec;46(12):909-13.


At the second stage, the patients with MAA progressed to SAA were given combined immunosuppressive (CIS) therapy (CIS group, a combination of ATG, CSA and high-dose immunoglobulin).
1(0,0,0,1) Details
16061683 Wang X, Ko EC, Peng L, Gillies SD, Ferrone S: Human high molecular weight melanoma-associated antigen mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: enhancement of immunogenicity of anti-idiotypic monoclonal antibody MK2-23 by fusion with interleukin 2. Cancer Res. 2005 Aug 1;65(15):6976-83.


Conjugation of human interleukin 2 (IL-2) to mAb MK2-23 variable regions covalently linked to human immunoglobulin constant regions enhanced mAb MK2-23 immunogenicity in BALB/c mice to an extent similar to that induced by mAb MK2-23 conjugated to KLH and given with Freund's adjuvant.
1(0,0,0,1) Details
4005860 Buraggi GL, Callegaro L, Mariani G, Turrin A, Cascinelli N, Attili A, Bombardieri E, Terno G, Plassio G, Dovis M, et al.: Imaging with 131I-labeled monoclonal antibodies to a high-molecular-weight melanoma-associated antigen in patients with melanoma: efficacy of whole immunoglobulin and its F (ab') 2 fragments. Cancer Res. 1985 Jul;45(7):3378-87.

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9430197 Mutz M, Hawthorne T, Ferrone S, Pluschke G: Titration calorimetry study of an anti-idiotypic antibody cascade in a human melanoma-associated antigen system. Mol Immunol. 1997 Jul;34(10):695-707.


The values of the binding enthalpy showed only small variations when binding of the idiotypic mAb CGP 76873 to four variants of the anti-idiotypic mAb CGP 60686 with different immunoglobulin constant regions, but identical variable regions were compared.
2(0,0,0,2) Details
17033770 Hua XF, Liu TC, Cao YC, Liu B, Wang HQ, Wang JH, Huang ZL, Zhao YD: Characterization of the coupling of quantum dots and immunoglobulin antibodies. Anal Bioanal Chem. 2006 Nov;386(6):1665-71. Epub 2006 Oct 11.

2(0,0,0,2) Details
9060545 Du Bois JS, Trehu EG, Mier JW, Shapiro L, Epstein M, Klempner M, Dinarello C, Kappler K, Ronayne L, Rand W, Atkins MB: Randomized placebo-controlled clinical trial of high-dose interleukin-2 in combination with a soluble p75 tumor necrosis factor receptor immunoglobulin G chimera in patients with advanced melanoma and renal cell carcinoma. J Clin Oncol. 1997 Mar;15(3):1052-62.

2(0,0,0,2) Details
19269415 Liu J, Zhao W, Fan RL, Wang WH, Tian ZQ, Peng J, Pang DW, Zhang ZL: Investigation of the nonspecific interaction between quantum dots and immunoglobulin G using Rayleigh light scattering. Talanta. 2009 May 15;78(3):700-4. Epub 2008 Dec 24.

2(0,0,0,2) Details
2576398 Boyages SC, Bloot AM, Maberly GF, Eastman CJ, Li M, Qian QD, Liu DR, van der Gaag RD, Drexhage HA: Thyroid autoimmunity in endemic goitre caused by excessive iodine intake. Clin Endocrinol. 1989 Oct;31(4):453-65.


Serum was tested for antimicrosomal (MAb), anti-thyroglobulin (TgAb), second colloid antigen antibodies (CA2-Ab) and TSH binding inhibitory immunoglobulins (TBII).
2(0,0,0,2) Details
12612978 Linossier MT, Palle S, Berthoux F: Different glycosylation profile of serum IgA1 in IgA nephropathy according to the glomerular basement membrane thickness: normal versus thin. Am J Kidney Dis. 2003 Mar;41(3):558-64.


BACKGROUND: Abnormal glycosylation of immunoglobulin A1 (IgA1) has been implicated in the pathophysiological characteristics of IgA nephropathy, leading to failure of normal clearance mechanisms and mesangial deposition of serum IgA1.
1(0,0,0,1) Details
10733543 Rolla R, Vay D, Mottaran E, Parodi M, Traverso N, Arico S, Sartori M, Bellomo G, Klassen LW, Thiele GM, Tuma DJ, Albano E: Detection of circulating antibodies against malondialdehyde-acetaldehyde adducts in patients with alcohol-induced liver disease. Hepatology. 2000 Apr;31(4):878-84.


Immunoglobulin G (IgG) reacting with MAA-modified proteins were significantly increased in the patients with alcohol-induced cirrhosis or hepatitis.
1(0,0,0,1) Details
1934623 Norton FL, Shuey SR, Kohler H: Response of huSCID mice reconstituted with lymphocytes from anti-idiotype-treated melanoma patients. Clin Immunol Immunopathol. 1991 Dec;61(3):332-42.


All of the huSCID mice reconstituted fully as evidenced by their production of human immunoglobulins.
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18623333 Kondo A, Teshima T: Preparation of immobilized enzyme with high activity using affinity tag based on proteins A and G. Biotechnol Bioeng. 1995 Jun 5;46(5):421-8.


Affinity tag AG consisting of immunoglobulin G (lgG)-binding domains of protein A from Staphylococcus aureus (EDABC) and those of protein G from Streptococcus strain G148 (C2C3) were used to facilitate immobilization of beta-galactosidase (betagal) from Escherichia coli.
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19156314 Chen YW, Rick J, Chou TC: A systematic approach to forming micro-contact imprints of creatine kinase. Org Biomol Chem. 2009 Feb 7;7(3):488-94. Epub 2008 Dec 15.


Re-binding the molecularly imprinted polymers (MIPs) with non-template proteins, namely myoglobin, human serum albumin (HSA) and immunoglobulin G (Ig G), showed these proteins to have comparatively little affinity for the CK imprinted films.
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11831396 Kinuya K, Kakuda K, Matano S, Sato S, Sugimoto T, Asakura H, Kinuya S, Michigishi T, Tonami N: Prevalence of deep venous thrombosis in the lower limbs and the pelvis and pulmonary embolism in patients with positive antiphospholipid antibodies. Ann Nucl Med. 2001 Dec;15(6):495-7.


BACKGROUND: Antiphospholipid antibodies (AA) are immunoglobulins that cross-react with phospholipid on cell membrane, and are therefore associated with a hypercoagulable state manifested by arterial/venous thromboses.
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