Protein Information

Name caspase 3
Synonyms Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor…

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
12502240 Takagi A, Yamada T, Hayashi K, Nakade Y, Kojima T, Takamatsu J, Shibata E, Ichihara G, Takeuchi Y, Murate T: Involvement of caspase 3 mediated apoptosis in hematopoietic cytotoxicity of metabolites of ethylene glycol monomethyl ether. Ind Health. 2002 Oct;40(4):371-4.

3(0,0,0,3) Details
19350633 Risberg K, Fodstad O, Andersson Y: The melanoma specific 9.2.27PE immunotoxin efficiently kills melanoma cells in vitro. Int J Cancer. 2009 Jul 1;125(1):23-33.


This is likely due to the lack of strong activation of caspase-8 and caspase-3.
2(0,0,0,2) Details
17962461 Jha P, Matta B, Lyzogubov V, Tytarenko R, Bora PS, Bora NS: Crucial role of apoptosis in the resolution of experimental autoimmune anterior uveitis. Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5091-100.


Caspase-3 levels peaked during the resolution of EAAU, and the upregulation of caspase-8 and -9 preceded that of caspase-3, suggesting that both extrinsic and intrinsic pathways of apoptosis are involved.
1(0,0,0,1) Details
15791436 Seidl C, Schrock H, Seidenschwang S, Beck R, Schmid E, Abend M, Becker KF, Apostolidis C, Nikula TK, Kremmer E, Schwaiger M, Senekowitsch-Schmidtke R: Cell death triggered by alpha-emitting 213Bi-immunoconjugates in HSC45-M2 gastric cancer cells is different from apoptotic cell death. Eur J Nucl Med Mol Imaging. 2005 Mar;32(3):274-85. Epub 2004 Oct 2.


Activation of caspase 3 after incubation of HSC45-M2 cells with both sorbitol and 213Bi-d9MAb was analysed via Western blotting.
1(0,0,0,1) Details
12220648 Rao AV, Shaha C: N-acetylcysteine prevents MAA induced male germ cell apoptosis: role of glutathione and cytochrome c. FEBS Lett. 2002 Sep 11;527(1-3):133-7.


Peak activation of caspase-9 and caspase-3 is detectable post treatment at 4 and 8 h respectively.
1(0,0,0,1) Details