Protein Information

Name MAPK (protein family or complex)
Synonyms MAPK; mitogen activated protein kinase; mitogen activated protein kinases

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
18035573 Souza CD, Evanson OA, Weiss DJ: Role of the mitogen-activated protein kinase pathway in the differential response of bovine monocytes to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. Microbes Infect. 2007 Nov-Dec;9(14-15):1545-52. Epub 2007 Sep 2.

Monocytes were incubated with MAP or Maa organisms with or without a specific inhibitor of the MAPK-p38 pathway (SB203580), and MAPK phosphorylation and antimicrobial functions of monocytes were evaluated.
196(2,3,3,6) Details
14564359 Maa SH, Wang CH, Liu CY, Lin HC, Huang KH, Kuo HP: Endogenous nitric oxide downregulates the Bcl-2 expression of eosinophils through mitogen-activated protein kinase in bronchial asthma. J Allergy Clin Immunol. 2003 Oct;112(4):761-7.

5(0,0,0,5) Details
18435575 Fong YC, Maa MC, Tsai FJ, Chen WC, Lin JG, Jeng LB, Yang RS, Fu WM, Tang CH: Osteoblast-derived TGF-beta1 stimulates IL-8 release through AP-1 and NF-kappaB in human cancer cells. J Bone Miner Res. 2008 Jun;23(6):961-70.


MAPK phosphorylation was examined using the Western blot method. siRNA was used to inhibit the expression of TGF-beta1, BMP-2, and IGF-1.
2(0,0,0,2) Details
15641147 Zhang HY, Han DW, Wang XG, Zhao YC, Zhou X, Zhao HZ: Experimental study on the role of endotoxin in the development of hepatopulmonary syndrome. World J Gastroenterol. 2005 Jan 28;11(4):567-72.


Overproduction of TNF-alpha due to endotoxin stimulation of Kupffer cells via mitogen-activated protein kinase (MAPK) signal transduction pathway may be a major mechanism mediating the pathologic alterations of hepatopulmonary syndrome.
1(0,0,0,1) Details
17062651 Murphy JT, Sommer S, Kabara EA, Verman N, Kuelbs MA, Saama P, Halgren R, Coussens PM: Gene expression profiling of monocyte-derived macrophages following infection with Mycobacterium avium subspecies avium and Mycobacterium avium subspecies paratuberculosis. Physiol Genomics. 2006 Dec 13;28(1):67-75. Epub 2006 Oct 24.


Over 41% of the differentially expressed genes in MAA and MAP infected MDM cells were members of, regulated by, or regulators of the MAPK pathways.
1(0,0,0,1) Details