| Name | CTLA 4 |
|---|---|
| Synonyms | CD152; GSE; CELIAC 3; CELIAC3; CTLA4; CD152 antigen; CTLA 4; Cytotoxic T lymphocyte antigen 4… |
| Name | MAA |
|---|---|
| CAS | methylarsonic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11481266 | Shao H, Woon MD, Nakamura S, Sohn JH, Morton PA, Bora NS, Kaplan HJ: Requirement of B7-mediated costimulation in the induction of experimental autoimmune anterior uveitis. Invest Ophthalmol Vis Sci. 2001 Aug;42(9):2016-21. CTLA4-Fc, a recombinant protein comprised of the extracellular domain of human CTLA4 bound to mouse IgG2a Fc, was used to block the CD28-B7 interaction. |
6(0,0,0,6) | Details |
| 18831916 | Pandolfi F, Cianci R, Lolli S, Dunn IS, Newton EE, Haggerty TJ, Boyle LA, Kurnick JT: Strategies to overcome obstacles to successful immunotherapy of melanoma. . Int J Immunopathol Pharmacol. 2008 Jul-Sep;21(3):493-500. These approaches include 1) immunostimulation: including peptide/protein based vaccines, dendritic cell vaccines, and adoptive cell transfer; and 2) overcoming immunosuppression, including targeting of checkpoint molecules such as CTLA-4, circumventing the activity of Tregs, and assuring antigen expression by tumor cells (thwarting antigen silencing). |
1(0,0,0,1) | Details |
| 12658546 | Shao H, Sun D, Sun SL, Cruze JM, Bora N, Kaplan HJ: Expression of B7 molecules in the eye during experimental autoimmune anterior uveitis (EAAU). Curr Eye Res. 2002 Nov;25(5):271-7. PURPOSE: We have reported that CTLA4-Fc, a fusion protein that binds B7, prevents the induction of EAAU and reduces the severity of disease in Lewis rats. |
1(0,0,0,1) | Details |