Protein Information

Name PP2
Synonyms NPY1RL; NPY6R; PP2; Y2B; Y6 encoding protein; neuropeptide Y receptor Y6 (pseudogene); Y6 encoding proteins; neuropeptide Y receptor Y6 (pseudogene)s

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
10698670 Wang W, Wine RN, Chapin RE: Rat testicular Src: normal distribution and involvement in ethylene glycol monomethyl ether-induced apoptosis. Toxicol Appl Pharmacol. 2000 Mar 1;163(2):125-34.


Furthermore, spermatocyte degeneration was significantly prevented by cotreatment with 0.1 microM geldanamycin, 10 microM herbimycin A, or 10 microM PP2, which are inhibitors of Src activity.
1(0,0,0,1) Details
15869794 Leu TH, Charoenfuprasert S, Yen CK, Fan CW, Maa MC: Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFalpha secretion in macrophages. Mol Immunol. 2006 Feb;43(4):308-16.


In this study, we demonstrate the upregulation of c-Src in Raw264.7 and peritoneal macrophages (PEMs) by LPS, which is inhibited by PP2 (an inhibitor for Src family kinases), pyrrolidinedithiocarbamate (PDTC; NF-kappaB inhibitor) and LY294002 (PI3K inhibitor).
4(0,0,0,4) Details