Protein Information

Name T cell receptors (protein family or complex)
Synonyms T cell Receptor; T cell Receptors

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
11092052 Abken H, Hombach A, Heuser C, Reinhold U: A novel strategy in the elimination of disseminated melanoma cells: chimeric receptors endow T cells with tumor specificity. Recent Results Cancer Res. 2001;158:249-64.


The strategy bypasses the requirement of presentation of melanoma-associated-antigen-derived peptides by the major histocompatibility complex to the T cell receptor complex by permanent grafting of T cells with a recombinant, chimeric T cell receptor.
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18831916 Pandolfi F, Cianci R, Lolli S, Dunn IS, Newton EE, Haggerty TJ, Boyle LA, Kurnick JT: Strategies to overcome obstacles to successful immunotherapy of melanoma. . Int J Immunopathol Pharmacol. 2008 Jul-Sep;21(3):493-500.


Finally, we discuss recent advances in gene therapy, including adoptive therapy with engineered T cell receptors (TCRs).
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1835714 Radrizzani M, Benedetti B, Castelli C, Longo A, Ferrara GB, Herlyn M, Parmiani G, Fossati G: Human allogeneic melanoma-reactive T-helper lymphocyte clones: functional analysis of lymphocyte-melanoma interactions. Int J Cancer. 1991 Dec 2;49(6):823-30.


The 55 clones tested displayed a CD3+, CD4+, CD8-, T-cell receptor (TCR) alpha/beta+, gamma/delta- phenotype.
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12471624 Losch FO, Muller R, Mutschler B, Neri D, Natali PG, Reth M, Carsetti R: Activation of T cells via tumor antigen specific chimeric receptors: the role of the intracellular signaling domain. Int J Cancer. 2003 Jan 20;103(3):399-407.


The intracellular tails were derived from the T-cell receptor zeta chain (TCR-zeta), from the B-cell receptor Ig-alpha molecule and from a mutated Ig-alpha molecule able of stronger signal transduction.
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