Protein Information

Name MM2
Synonyms 40 kDa neuronal protein; 40 kd neuronal protein; MA2; MM2; Onconeuronal antigen MA2; PNMA 2; PNMA2; Paraneoplastic antigen Ma2…

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
9579583 Li M, Xu F, Muller J, Hearing VJ, Gorelik E: Ecotropic C-type retrovirus of B16 melanoma and malignant transformation of normal melanocytes. Int J Cancer. 1998 May 4;76(3):430-6.


We reported previously that B16,JB/RH and JB/MS melanomas of C57BL/6 mice express the common melanoma-associated antigen (MAA) recognized by MM2-9B6 monoclonal antibody (MAb).
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9918881 Li M, Xu F, Muller J, Huang X, Hearing VJ, Gorelik E: Loss of retrovirus production in JB/RH melanoma cells transfected with H-2Kb and TAP-1 genes. Virology. 1999 Jan 20;253(2):230-40.


When JB/RH1 cells were transfected with the H-2Kb and cotransfected with the TAP-1 gene, it resulted in the appearance of H-2Kb molecules and an increase in their immunogenicity, albeit they lost expression of retrovirus-encoded MAA recognized by MM2-9B6 mAb.
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1913644 Gorelik E, Jay G, Kim M, Hearing VJ, DeLeo A, McCoy JP Jr: Effects of H-2Kb gene on expression of melanoma-associated antigen and lectin-binding sites on BL6 melanoma cells. Cancer Res. 1991 Oct 1;51(19):5212-8.


The effects of the transfected genes on the expression of the melanoma-associated antigen (MAA) recognized by the monoclonal antibodies MM2-9B6 and MM2-3C6 and the cell surface carbohydrates recognized by 15 different lectins were studied.
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8813142 Li M, Muller J, Xu F, Hearing VJ, Gorelik E: Inhibition of melanoma-associated antigen expression and ecotropic retrovirus production in B16BL6 melanoma cells transfected with major histocompatibility complex class I genes. Cancer Res. 1996 Oct 1;56(19):4464-74.


We have previously reported that expression of the melanoma-associated antigen (MAA) recognized by MM2-9B6 monoclonal antibody in B16 melanoma was closely associated with C-type ecotropic retroviral particle production.
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