Protein Information

Name bcl 2
Synonyms Apoptosis regulator Bcl 2; B cell CLL/lymphoma 2; B cell lymphoma protein 2 alpha; B cell lymphoma protein 2 alpha isoform; BCL2; Bcl 2; B cell CLL/lymphoma 2s; B cell lymphoma protein 2 alphas…

Compound Information

Name MAA
CAS methylarsonic acid

Reference List

PubMed Abstract RScore(About this table)
14564359 Maa SH, Wang CH, Liu CY, Lin HC, Huang KH, Kuo HP: Endogenous nitric oxide downregulates the Bcl-2 expression of eosinophils through mitogen-activated protein kinase in bronchial asthma. J Allergy Clin Immunol. 2003 Oct;112(4):761-7.

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12690298 Kamei T, Inui M, Nakamura S, Okumura K, Goto A, Tagawa T: Interferon-gamma and anti-Fas antibody-induced apoptosis in human melanoma cell lines and its relationship to bcl-2 cleavage and bak expression. Melanoma Res. 2003 Apr;13(2):153-9.

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17962461 Jha P, Matta B, Lyzogubov V, Tytarenko R, Bora PS, Bora NS: Crucial role of apoptosis in the resolution of experimental autoimmune anterior uveitis. Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5091-100.


There was an inverse relationship between the expression of proapoptotic protein Bax and antiapoptotic protein Bcl-2 during EAAU.
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19350633 Risberg K, Fodstad O, Andersson Y: The melanoma specific 9.2.27PE immunotoxin efficiently kills melanoma cells in vitro. Int J Cancer. 2009 Jul 1;125(1):23-33.


This suggests that Bcl-2 may play a role in maintaining the mitochondrial membrane integrity in the 9.2.27PE-treated cells.
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17767397 : Oblimersen: Augmerosen, BCL-2 antisense oligonucleotide - Genta, G 3139, GC 3139, oblimersen sodium. Drugs R D. 2007;8(5):321-34.


Oblimersen targets the first six codons of Bcl-2 mRNA to form a DNA/RNA complex.
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