Protein Information

Name cyclooxygenase 2
Synonyms COX 2; COX2; PHS2; PGG/HS; Cyclooxygenase 2; Cyclooxygenase 2b; Cycloxygenase 2; PGH synthase 2…

Compound Information

Name lindane
CAS (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
10426785 Kroll B, Kunz S, Klein T, Schwarz LR: Effect of lindane and phenobarbital on cyclooxygenase-2 expression and prostanoid synthesis by Kupffer cells. Carcinogenesis. 1999 Aug;20(8):1411-6.
31(0,1,1,1) Details
18834901 Toscano CD, Kingsley PJ, Marnett LJ, Bosetti F: NMDA-induced seizure intensity is enhanced in COX-2 deficient mice. Neurotoxicology. 2008 Nov;29(6):1114-20. Epub 2008 Sep 11.


To further understand the involvement of COX-2 in regulating susceptibility to excitotoxicity, we investigated the effect of COX-2 deletion on excitotoxicity induced by peripheral injection of N-methyl-d-aspartate (NMDA, a specific agonist of the NMDA receptors) or lindane (a GABA (A) receptor antagonist).
0(0,0,0,0) Details