| Name | histone deacetylase (protein family or complex) |
|---|---|
| Synonyms | Histone deacetylase; Histone deacetylases |
| Name | MAA |
|---|---|
| CAS | methylarsonic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 14699156 | Leu TH, Yeh HH, Huang CC, Chuang YC, Su SL, Maa MC: Participation of p97Eps8 in Src-mediated transformation. J Biol Chem. 2004 Mar 12;279(11):9875-81. Epub 2003 Dec 29. Histone acetylase and histone deacetylase are two crucial enzymes that determine the structure of chromatin, regulating gene expression. |
2(0,0,0,2) | Details |
| 20049119 | Henley DV, Mueller S, Korach KS: The short-chain fatty acid methoxyacetic acid disrupts endogenous estrogen receptor-alpha-mediated signaling. Environ Health Perspect. 2009 Nov;117(11):1702-6. Epub 2009 Jun 16. The primary metabolite of EGME is methoxyacetic acid (MAA), a short-chain fatty acid that inhibits histone deacetylase activity and alters gene expression. |
1(0,0,0,1) | Details |
| 20149623 | Maa MC, Chang MY, Hsieh MY, Chen YJ, Yang CJ, Chen ZC, Li YK, Yen CK, Wu RR, Leu TH: reduced lipopolysaccharide-mediated macrophage migration by suppression of Src enhancement and focal adhesion kinase activity. J Nutr Biochem. 2010 Feb 8. As a major short-chain fatty acid with histone deacetylase (HDAC) inhibitor activity, exerts anti-inflammatory effect by regulating the expression of cytokines. |
1(0,0,0,1) | Details |
| 18199887 | Wade MG, Kawata A, Williams A, Yauk C: Methoxyacetic acid-induced spermatocyte death is associated with histone hyperacetylation in rats. Biol Reprod. 2008 May;78(5):822-31. Epub 2008 Jan 16. MAA treatment of testis nuclear protein extracts from unexposed animals caused both a significant increase in histone acetyltransferase activity and a significant inhibition of histone deacetylase activity, suggesting that increased core histone acetylation results from a combination of these complementary modes of action. |
1(0,0,0,1) | Details |