Protein Information

Name hormone receptors
Synonyms Early response protein NAK1; GFRP 1; GFRP1; Growth factor inducible nuclear protein N10; Growth factor response protein 1; HMR; Hormone receptor; N10…

Compound Information

Name MAMA
CAS ammonium hydrogen methylarsonate

Reference List

PubMed Abstract RScore(About this table)
17352236 Martinez-Arribas F, Alvarez T, Del Val G, Martin-Garabato E, Nunez-Villar MJ, Lucas R, Sanchez J, Tejerina A, Schneider J: Bcl-2 expression in breast cancer: a comparative study at the mRNA and protein level. Anticancer Res. 2007 Jan-Feb;27(1A):219-22.


Additionally, the expression of hormone receptors (ER and PR), c-erb-B2, p53 and the proliferation-associated Ki-67 antigen were also studied by means of immunohistochemistry as part of the standard pathological workup.
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12556966 Schneider J, Pollan M, Tejerina A, Sanchez J, Lucas AR: Accumulation of uPA-PAI-1 complexes inside the tumour cells is associated with axillary nodal invasion in progesterone-receptor-positive early breast cancer. Br J Cancer. 2003 Jan 13;88(1):96-101.


Using this technique, we have studied a series of 212 early (pT1) unifocal breast cancers and have correlated the expression of uPA-PAI-1 complexes, together with other clinical and biological features (histologic variety, histologic and nuclear grade, hormone receptors, Ki67 labelling index, c-erb-B2-, p53- and CD44std-expression) with or without the occurrence of axillary node invasion.
2(0,0,0,2) Details
12680147 Martinez-Arribas F, Nunez-Villar MJ, Lucas AR, Sanchez J, Tejerina A, Schneider J: Immunofluorometric study of Bcl-2 and Bax expression in clinical fresh tumor samples from breast cancer patients. Anticancer Res. 2003 Jan-Feb;23(1B):565-8.


Paraffin blocks corresponding to the same tumors were used for immunohistochemistry, to study the expression of hormone receptors (ER and PR), p53, c-erb-B2 and the Ki67 labelling index.
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18820371 Martin-Garabato E, Martinez-Arribas F, Pollan M, Lucas AR, Sanchez J, Schneider J: The small variant of the apoptosis-associated X-chromosome RBM10 gene is co-expressed with caspase-3 in breast cancer. Cancer Genomics Proteomics. 2008 May-Aug;5(3-4):169-73.


The correlation with the expression of hormone receptors, c-erb-B2, mutant p53 and Ki-67, all measured by means of immunohistochemistry, was also studied, as well as that with standard clinical parameters such as histological type, tumor size, axillary metastasis and DNA-ploidy.
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16475699 Martinez-Arribas F, Martin-Garabato E, Lafuente P, Tejerina A, Lucas R, Sanchez J, Schneider J: Proliferation measurement in breast cancer by two different methods. Anticancer Res. 2006 Jan-Feb;26(1A):199-202.


Furthermore, hormone receptor (estrogen receptor, ER; progesterone receptor, PR), c-erb-B2 and p53 expressions were studied using the same method.
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19035283 Martinez-Arribas F, Martin-Garabato E, Zapardiel I, Sanchez J, Lucas AR, Tejerina A, Schneider J: Bax expression in untreated breast cancer: an immunocytometric study of 255 cases. Anticancer Res. 2008 Sep-Oct;28(5A):2595-8.


As variables of the study for the final statistical analysis, the histological variety of the tumors, histological and nuclear grade, the expression of hormone receptors, p53, Ki-67 or c-erb-B2, axillary node invasion, tumor size and DNA-ploidy were also included.
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11205274 Schneider J, Lucas R, Sanchez J, Ruibal A, Tejerina A, Martin M: Modulation of molecular marker expression by induction chemotherapy in locally advanced breast cancer: correlation with the response to therapy and the expression of MDR1 and LRP. Anticancer Res. 2000 Nov-Dec;20(6B):4373-7.

METHODS: Between 1995 and 1999, 48 patients with locally advanced breast cancer were submitted to induction chemotherapy at Fundacion Tejerina--Centro de Patologia de la Mama, Madrid, Spain.
Core biopsies were performed in all cases prior to treatment for histological diagnosis which allowed for the determination of the following parameters by means of immunohistochemistry: hormone receptors (ER and PR), oncogenes and tumor suppressor genes (c-erb-B2 and p53) and the proliferation marker Ki67.
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15816610 Hernandez L, Nunez-Villarl MJ, Martinez-Arribas F, Pollan M, Schneider J: Circulating hormone levels in breast cancer patients. correlation with serum tumor markers and the clinical and biological features of the tumors. Anticancer Res. 2005 Jan-Feb;25(1B):451-4.


All tumors were studied after surgery for hormone receptor (ER and PR), Ki67, c-erb-B2 and p53 expression by means of immunohistochemistry, and for DNA-ploidy by means of flow cytometry.
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15980994 Martinez-Arribas F, Nunez-Villar MJ, Lucas AR, Sanchez J, Tejerina A, Schneider J: The S-phase fraction of the aneuploid cell subpopulation is the biologically relevant one in aneuploid breast cancers. Breast Cancer Res Treat. 2005 Jul;92(1):77-80.


Flow cytometry was performed on fresh tumor tissue, and immunohistochemistry for hormone receptors, Ki67, c-erb-B2 and p53 on paraffin-embedded material.
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