| Name | ubiquitin |
|---|---|
| Synonyms | HMG20; RPS27A; UBA80; UBCEP 1; UBCEP1; UBA52; UBCEP 2; UBCEP2… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16926164 | Santos C, Gaspar M, Caeiro A, Branco-Price C, Teixeira A, Ferreira RB: Exposure of Lemna minor to arsenite: expression levels of the components and intermediates of the ubiquitin/proteasome pathway. Plant Cell Physiol. 2006 Sep;47(9):1262-73. Epub 2006 Aug 22. |
5(0,0,0,5) | Details |
| 15362974 | McNeill H, Knebel A, Arthur JS, Cuenda A, Cohen P: A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. Biochem J. 2004 Dec 1;384(Pt 2):391-400. |
3(0,0,0,3) | Details |
| 16239170 | Tsou TC, Tsai FY, Hsieh YW, Li LA, Yeh SC, Chang LW: Arsenite induces endothelial cytotoxicity by down-regulation of vascular endothelial nitric oxide synthase. Toxicol Appl Pharmacol. 2005 Nov 1;208(3):277-84. We found that inhibition of the ubiquitin-proteasome pathway by MG-132 could partially protect Akt1 and eNOS from degradation by arsenite together with a proportional protection from the arsenite-induced cytoxicity. |
2(0,0,0,2) | Details |
| 1747062 | Lee TC, Kao SL, Yih LH: Suppression of sodium arsenite-potentiated cytotoxicity of ultraviolet light by cycloheximide in Chinese hamster ovary cells. Arch Toxicol. 1991;65(8):640-5. This small stress protein was demonstrated as ubiquitin by immunoprecipitation. |
2(0,0,0,2) | Details |
| 18417180 | Wang XJ, Sun Z, Chen W, Li Y, Villeneuve NF, Zhang DD: Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction. Toxicol Appl Pharmacol. 2008 Aug 1;230(3):383-9. Epub 2008 Mar 12. Previously, we reported that activation of the Nrf2-mediated cellular defense pathway confers protection against toxic effects induced by sodium arsenite [As (III)] or monomethylarsonous acid [MMA (III)]. Arsenic markedly enhanced the interaction between Keap1 and Cul3, subunits of the E3 ubiquitin ligase for Nrf2, which led to impaired dynamic assembly/disassembly of the E3 ubiquitin ligase and thus decreased its ligase activity. |
1(0,0,0,1) | Details |
| 17373649 | Li JP, Yang JL: Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite. J Cell Physiol. 2007 Aug;212(2):481-8. This rapid destruction of cyclin B1 was mediated via the ubiquitin-proteasome pathway probably in a Cdc20 and Cdh1 independent mechanism. |
1(0,0,0,1) | Details |
| 16283521 | Othumpangat S, Kashon M, Joseph P: Sodium arsenite-induced inhibition of eukaryotic translation initiation factor 4E (eIF4E) results in cytotoxicity and cell death. Mol Cell Biochem. 2005 Nov;279(1-2):123-31. Cellular levels of ubiquitin and the process of ubiquitination were significantly higher in the NaAsO2-treated cells compared with the control cells. |
1(0,0,0,1) | Details |
| 1572905 | Li JJ, Dewey WC: Relationship between thermal tolerance and protein degradation in temperature-sensitive mouse cells. J Cell Physiol. 1992 May;151(2):310-7. At the nonpermissive temperature of 39 degrees C, ts85 cells are defective in the degradation of short-lived abnormal proteins, apparently because of loss of activity of a ubiquitin-activating enzyme. |
1(0,0,0,1) | Details |
| 17170114 | Jiang HY, Jiang L, Wek RC: The eukaryotic initiation factor-2 kinase pathway facilitates differential GADD45a expression in response to environmental stress. J Biol Chem. 2007 Feb 9;282(6):3755-65. Epub 2006 Dec 14. Those stress agents that enhance ATF4-directed GADD45a transcription and impede the turnover of GADD45a protein by blocking ubiquitin/proteasome-mediated degradation elevate GADD45a protein levels. |
1(0,0,0,1) | Details |
| 3127388 | Desrosiers R, Tanguay RM: Methylation of Drosophila histones at and residues during heat shock. J Biol Chem. 1988 Apr 5;263(10):4686-92. Moreover, we suggest that the hypermethylation of H2B may also be involved in its protection from increased ubiquitin-mediated proteolytic activity under these conditions of cellular stress. |
1(0,0,0,1) | Details |