| Name | cyclooxygenase 2 |
|---|---|
| Synonyms | COX 2; COX2; PHS2; PGG/HS; Cyclooxygenase 2; Cyclooxygenase 2b; Cycloxygenase 2; PGH synthase 2… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15056798 | Trouba KJ, Germolec DR: Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes. Toxicol Sci. 2004 Jun;79(2):248-57. Epub 2004 Mar 31. |
32(0,1,1,2) | Details |
| 15733543 | Ialenti A, Di Meglio P, D'Acquisto F, Pisano B, Maffia P, Grassia G, Di Rosa M, Ianaro A: Inhibition of cyclooxygenase-2 gene expression by the heat shock response in J774 murine macrophages. Eur J Pharmacol. 2005 Feb 21;509(2-3):89-96. The heat shock response is a highly conserved mechanism of protection elicited in the cell by various kinds of stimuli, such as heat, sodium arsenite, oxidants and inflammation. |
4(0,0,0,4) | Details |
| 12392964 | Bunderson M, Coffin JD, Beall HD: Arsenic induces generation and cyclooxygenase-2 protein expression in aortic endothelial cells: possible role in atherosclerosis. Toxicol Appl Pharmacol. 2002 Oct 1;184(1):11-8. We found that production of a strong oxidant formed from the coupling of and was significantly increased in bovine aortic endothelial (BAE) cells exposed to sodium arsenite at concentrations as low as 0.5 microM. |
2(0,0,0,2) | Details |
| 17906315 | Chai CY, Huang YC, Hung WC, Kang WY, Chen WT: Arsenic salt-induced DNA damage and expression of mutant p53 and COX-2 proteins in SV-40 immortalized human uroepithelial cells. Mutagenesis. 2007 Nov;22(6):403-8. Epub 2007 Sep 28. In addition, over-expression of mutant p53 and cyclooxygenase-2 (COX-2) frequently occurs in a variety of human malignancies. In this study, the relative genotoxicity of sodium arsenite was evaluated in SV-40 immortalized human uroepithelial cells (SV-HUC-1) using the alkaline comet assay. |
1(0,0,0,1) | Details |
| 16487513 | Ivanov VN, Hei TK: Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells. Exp Cell Res. 2006 May 1;312(8):1401-17. Epub 2006 Feb 17. We report here the use of a combination of sodium arsenite, an inhibitor of NF-kappaB activation, and NS398, a cyclooxygenase-2 (COX-2) inhibitor, for restoration of the surface FasL expression. |
1(0,0,0,1) | Details |
| 18329681 | Aguirre-Banuelos P, Escudero-Lourdes C, Sanchez-Pena LC, Del Razo LM, Perez-Urizar J: Inorganic arsenic exposure affects pain behavior and inflammatory response in rat. Toxicol Appl Pharmacol. 2008 Jun 15;229(3):374-85. Epub 2008 Feb 7. In vitro studies have suggested that iAs can modulate the activity of macrophages producing an over-expression of cyclooxygenase-2 (COX-2) and resulting in an increase in (2) (PGE (2)) concentrations in endothelial cells. Rats were given a single dose of sodium arsenite (0.1, 1 and 10 mg/kg i.p.) or submitted to subchronic exposure to arsenic added to the drinking water for 4 weeks (0.1, 1, 10 and 100 ppm). |
1(0,0,0,1) | Details |