| Name | TRAIL R1 |
|---|---|
| Synonyms | APO 2; APO2; CD261; CD261 antigen; DR4; Death receptor 4; TNF related apoptosis inducing ligand receptor 1; TNFRSF10A… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17070520 | Ivanov VN, Hei TK: Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. Exp Cell Res. 2006 Dec 10;312(20):4120-38. Epub 2006 Sep 28. |
83(1,1,1,3) | Details |
| 17545621 | Ivanov VN, Zhou H, Hei TK: Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells. Cancer Res. 2007 Jun 1;67(11):5397-407. We show in the present study that gamma-irradiation, as well as alpha-particle exposure, dramatically increases the susceptibility of melanoma cells to recombinant tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis via up-regulation of surface TRAIL-receptor 1/receptor 2 (DR4/DR5) levels and to Fas ligand-mediated apoptosis via up-regulation of surface Fas levels. |
1(0,0,0,1) | Details |
| 18222423 | Ivanov VN, Partridge MA, Johnson GE, Huang SX, Zhou H, Hei TK: sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression. Exp Cell Res. 2008 Mar 10;314(5):1163-76. Epub 2007 Dec 23. Although many human melanomas express the death receptors TRAIL-R2/DR5 or TRAIL-R1/DR4 on cell surface, they often exhibit resistance to exogenous TRAIL. Interestingly, did not increase surface expression of DR5 in human melanomas, while gamma-irradiation or sodium arsenite treatment substantially upregulated DR5 expression. |
1(0,0,0,1) | Details |