| Name | HSF1 |
|---|---|
| Synonyms | HSF 1; HSTF1; HSF1; HSTF 1; Heat shock factor protein 1; Heat shock transcription factor 1; Heat shock factor 1; Heat shock factor protein 1s… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8663271 | Elia G, De Marco A, Rossi A, Santoro MG: Inhibition of HSP70 expression by ionophore A23187 in human cells. J Biol Chem. 1996 Jul 5;271(27):16111-8. In this study, we report that the ionophore A23187, -regulated protein (GRP) inducer, dramatically inhibits HSP70 synthesis and HSP70 mRNA transcription after induction by heat shock, sodium arsenite, or treatment in human K562 cells. |
0(0,0,0,0) | Details |
| 14673132 | Wadekar SA, Li D, Sanchez ER: Agonist-activated glucocorticoid receptor inhibits binding of heat shock factor 1 to the heat shock protein 70 promoter in vivo. Mol Endocrinol. 2004 Mar;18(3):500-8. Epub 2003 Dec 12. Dexamethasone inhibited HSF1 binding at the Hsp70 promoter in response to heat or chemical shock (sodium arsenite). |
91(1,1,1,11) | Details |
| 9182569 | Tanabe M, Nakai A, Kawazoe Y, Nagata K: Different thresholds in the responses of two heat shock transcription factors, HSF1 and HSF3. J Biol Chem. 1997 Jun 13;272(24):15389-95. We also observed that cHSF3 was activated by treating cells with higher concentrations of sodium arsenite compared to cHSF1. |
4(0,0,0,4) | Details |
| 10600494 | Hatayama T, Hayakawa M: Differential temperature dependency of chemical stressors in HSF1-mediated stress response in mammalian cells. Biochem Biophys Res Commun. 1999 Nov 30;265(3):763-9. Hsp70 was not induced by treatment with sodium arsenite, azetidine-2-carboxylic acid, or zinc at the level of heat shock factor (HSF) 1 activation in cells incubated at low temperature, although these treatments induced hsp70 in cells incubated at 37 degrees C. |
3(0,0,0,3) | Details |
| 8717371 | Dewji NN, Do C: Heat shock factor-1 mediates the transcriptional activation of Alzheimer's beta-amyloid precursor protein gene in response to stress. Brain Res Mol Brain Res. 1996 Jan;35(1-2):325-8. Recently we demonstrated [4] that stress, in the form of heat shock, and sodium arsenite treatment, transcriptionally activates the beta-APP gene. |
2(0,0,0,2) | Details |
| 9837746 | Kitagawa M, Mukai H, Takahashi M, Ono Y: The role of PKN in the regulation of alphaB-crystallin expression via heat shock transcription factor 1. Biochem Biophys Res Commun. 1998 Nov 27;252(3):561-5. We previously reported that PKN, a fatty acid-activated serine/threonine protein kinase, translocates from the cytosol to the nucleus by stresses such as heat shock, sodium arsenite, and serum starvation. |
2(0,0,0,2) | Details |
| 9873828 | Kim SH, Yeo GS, Lim YS, Kang CD, Kim CM, Chung BS: Suppression of multidrug resistance via inhibition of heat shock factor by in MDR cells. Exp Mol Med. 1998 Jun 30;30(2):87-92. Therefore, it was examined whether which has been shown to interfere with the formation of the complex between HSE and HSF, and to downregulate the level of HSF1, can sensitize MDR cells against anticancer drugs by inhibition of HSF DNA-binding activity. In this study, appeared to inhibit the constitutive HSF DNA-binding activity and the sodium arsenite-induced HSF DNA-binding activity in the MDR cells. |
1(0,0,0,1) | Details |
| 11322385 | Chen YC, Tsai SH, Shen SC, Lin JK, Lee WR: Alternative activation of extracellular signal-regulated protein kinases in and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells. Eur J Cell Biol. 2001 Mar;80(3):213-21. Our data show that chemical treatments including sodium arsenite and induced significant synthesis of HSP70 and its mRNA. The increase in HSP70 gene expression by both chemicals is associated with an increase in HSF binding to HSE and induction of HSF1 di- or trimerization. |
1(0,0,0,1) | Details |
| 19358893 | Young JT, Gauley J, Heikkila JJ: Simultaneous exposure of Xenopus A6 kidney epithelial cells to concurrent mild sodium arsenite and heat stress results in enhanced hsp30 and hsp70 gene expression and the acquisition of thermotolerance. Comp Biochem Physiol A Mol Integr Physiol. 2009 Aug;153(4):417-24. Epub 2009 Apr 7. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation. |
1(0,0,0,1) | Details |
| 7930803 | Mivechi NF, Koong AC, Giaccia AJ, Hahn GM: Analysis of HSF-1 phosphorylation in A549 cells treated with a variety of stresses. Int J Hyperthermia. 1994 May-Jun;10(3):371-9. In the absence of stress, heat shock transcription factor-1 (HSF-1) exists as a monomer. Our studies show that HSF-1 is phosphorylated following heat shock (43 degrees C for 1 h), hypoxia (5 h exposure to 0.02% 8% (1 h exposure at 37 degrees C), or 200 microM sodium arsenite (1 h exposure at 37 degrees C). |
1(0,0,0,1) | Details |
| 18675372 | Voyer J, Heikkila JJ: Comparison of the effect of heat shock factor inhibitor, KNK437, on heat shock- and chemical stress-induced hsp30 gene expression in Xenopus laevis A6 cells. Comp Biochem Physiol A Mol Integr Physiol. 2008 Oct;151(2):253-61. Epub 2008 Jul 10. Previously, KNK437 was shown to inhibit HSE-HSF1 binding activity and heat-induced hsp gene expression. In the present study, Northern and Western blot analysis revealed that pretreatment of A6 cells with KNK437 inhibited hsp30 mRNA and HSP30 and HSP70 protein accumulation induced by chemical stressors including sodium arsenite, cadmium and herbimycin A. |
1(0,0,0,1) | Details |
| 15453632 | Demarco VG, Scumpia PO, Bosanquet JP, Skimming JW: inhibits endotoxin-stimulated expression of iNOS and independent of the heat shock response in RAW 264.7 cells. Free Radic Res. 2004 Jul;38(7):675-82. Several inducers of the heat shock response, such as hyperthermia, sodium arsenite, and pyrollidine dithiocarbonate, inhibit NF-kappaB activation and formation. To test this hypothesis, we determined whether exposure to LA affects expression of both heat shock protein 70 (HSP-70) and nuclear heat shock factor-1 (HSF-1) in lipopolysaccharide (LPS) stimulated macrophages. |
1(0,0,0,1) | Details |
| 9443804 | Hatayama T, Takahashi H, Yamagishi N: Reduced induction of HSP70 in PC12 cells during neuronal differentiation. J Biochem. 1997 Nov;122(5):904-10. The induction of HSP70 and HSP70 mRNA following these stresses was diminished in the differentiated PC12 cells compared to the undifferentiated cells, whereas the HSF1 DNA-binding activity was enhanced in the differentiated PC12 cells. |
1(0,0,0,1) | Details |
| 15327774 | Thomson S, Hollis A, Hazzalin CA, Mahadevan LC: Distinct stimulus-specific histone modifications at hsp70 chromatin targeted by the transcription factor heat shock factor-1. Mol Cell. 2004 Aug 27;15(4):585-94. The stress-inducible gene Hsp70 is activated by heat shock or by sodium arsenite. |
1(0,0,0,1) | Details |