Protein Information

Name vascular endothelial growth factor
Synonyms VEGF; VEGF A; VEGFA; VPF; Vascular endothelial growth factor A; Vascular endothelial growth factor A precursor; Vascular permeability factor; vascular endothelial growth factor…

Compound Information

Name sodium arsenite
CAS sodium arsenenite

Reference List

PubMed Abstract RScore(About this table)
12482858 Duyndam MC, Hulscher ST, van der Wall E, Pinedo HM, Boven E: Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite. J Biol Chem. 2003 Feb 28;278(9):6885-95. Epub 2002 Dec 13.
38(0,1,2,3) Details
12703962 Kao YH, Yu CL, Chang LW, Yu HS: Low concentrations of arsenic induce vascular endothelial growth factor and nitric oxide release and stimulate angiogenesis in vitro. Chem Res Toxicol. 2003 Apr;16(4):460-8.

The results revealed that lower concentrations (up to 1 microM) of sodium arsenite stimulated HUVEC cell growth.
3(0,0,0,3) Details
20083128 Meng D, Wang X, Chang Q, Hitron A, Zhang Z, Xu M, Chen G, Luo J, Jiang B, Fang J, Shi X: Arsenic promotes angiogenesis in vitro via a heme oxygenase-1-dependent mechanism. Toxicol Appl Pharmacol. 2010 Jan 18.

Knock down of HO-1 expression decreased arsenite-induced VEGF expression, cell migration, and tube formation.
The present study investigates the role of heme oxygenase-1 (HO-1) in sodium arsenite-mediated angiogenesis in vitro.
1(0,0,0,1) Details