| Name | PARP |
|---|---|
| Synonyms | COL11A2; PARP; Collagen alpha 2(XI) chain; Collagen alpha 2(XI) chain precursor; Collagen type XI alpha 2; Collagen type XI alpha 2 isoform 1; DFNA13; DFNB53… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19616567 | Ghosh J, Das J, Manna P, Sil PC: prevents arsenic-induced cardiac oxidative stress and apoptotic damage: role of NF-kappa B, p38 and JNK MAPK pathway. Toxicol Appl Pharmacol. 2009 Oct 1;240(1):73-87. Epub 2009 Jul 17. Arsenic reduced cardiomyocyte viability, increased reactive species (ROS) production and intracellular overload, and induced apoptotic cell death by mitochondrial dependent caspase-3 activation and poly-ADP polymerase (PARP) cleavage. |
2(0,0,0,2) | Details |
| 19536524 | Wang Y, Xu Y, Wang H, Xue P, Li X, Li B, Zheng Q, Sun G: Arsenic induces mitochondria-dependent apoptosis by reactive species generation rather than depletion in Chang human hepatocytes. Arch Toxicol. 2009 Oct;83(10):899-908. Epub 2009 Jun 18. The MTT assay demonstrated that sodium arsenite (NaAsO2) treatment for 24 h caused a dose-dependent decrease of cell viability. NaAsO2 treatment (0-30 microM) was also found to induce externalization, a hallmark of apoptosis; to disrupt the mitochondrial membrane potential (Deltapsi ( m )); to cause the release of cytochrome c into the cytosol, and to trigger cleavage of caspase-3 and poly (ADP- polymerase (PARP) in a dose-dependent manner. |
1(0,0,0,1) | Details |
| 20188806 | Xu Y, Wang H, Wang Y, Zheng Y, Sun G: Effects of on arsenic toxicity in Chang human hepatocytes: Involvement of antioxidant properties. Toxicol Lett. 2010 Feb 25. Cells were cultured in -deficient medium, normal medium or -supplemented medium for 1h and then co-treated with or without 20-muM sodium arsenite (NaAsO (2)) for 24h. The results showed that folate deficiency significantly aggravated the NaAsO (2)-induced apoptotic progression [evidenced by externalization, cleavage of capspase-3 and poly (ADP- polymerase (PARP), collapse of mitochondrial potential, and release of cytochrome c from the mitochondria] and decrease of cell viability. |
1(0,0,0,1) | Details |
| 10652248 | Mirkes PE, Little SA: Cytochrome c release from mitochondria of early postimplantation murine embryos exposed to 4-hydroperoxycyclophosphamide, heat shock, and staurosporine. Toxicol Appl Pharmacol. 2000 Feb 1;162(3):197-206. Previously, we showed that the cell death induced in day 9 mouse embryos by three teratogens, hyperthermia (HS), 4-hydroperoxycyclophosphamide (4-CP), and sodium arsenite (As), is apoptotic in nature involving the activation of caspase-3, cleavage of poly (ADP- polymerase (PARP), and DNA fragmentation. |
32(0,1,1,2) | Details |
| 10200514 | Mirkes PE, Little SA: Teratogen-induced cell death in postimplantation mouse embryos: differential tissue sensitivity and hallmarks of apoptosis. Cell Death Differ. 1998 Jul;5(7):592-600. We show that three teratogens, hyperthermia, cyclophosphamide and sodium arsenite induce an increase in cell death in day 9.0 mouse embryos with concurrent induction of DNA fragmentation, activation of caspase-3 and the cleavage of poly (ADP- polymerase (PARP). |
32(0,1,1,2) | Details |
| 9219571 | Yager JW, Wiencke JK: Inhibition of poly (ADP- polymerase by arsenite. . Mutat Res. 1997 Jun;386(3):345-51. The effect of treatment with sodium arsenite on PARP activity was assessed as follows: Molt-3 cells (a human T-cell lymphoma-derived cell line) in culture were treated for 24 h with concentrations of sodium arsenite ranging from 2.5 up to 25 microM. |
10(0,0,1,5) | Details |
| 17849503 | Watcharasit P, Thiantanawat A, Satayavivad J: GSK3 promotes arsenite-induced apoptosis via facilitation of mitochondria disruption. J Appl Toxicol. 2008 May;28(4):466-74. Investigation of the involvement of GSK3 in arsenite-induced apoptosis demonstrated that arsenite induced apoptosis in SH-SY5Y human neuroblastoma cells, activating the executioner caspase-3 which caused cleavage of poly-ADP -polymerase (PARP). |
2(0,0,0,2) | Details |
| 11035063 | Hossain K, Akhand AA, Kato M, Du J, Takeda K, Wu J, Takeuchi K, Liu W, Suzuki H, Nakashima I: Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase. J Immunol. 2000 Oct 15;165(8):4290-7. Additionally, staurosporine, which severely inhibited the activation of mitogen-activated protein (MAP) family kinases and c-Jun, partially blocked the NaAsO (2)-mediated signal for poly (ADP- polymerase (PARP) degradation. |
2(0,0,0,2) | Details |
| 19580012 | Alarifi SA, Alkahtani S, Tarboush FM, Al-Qahtani A: Effect of DNA hypomethylation on genotoxicity and apoptogenicity of sodium arsenite in laboratory mice. Pak J Biol Sci. 2009 Apr 1;12(7):554-64. |
0(0,0,0,0) | Details |
| 20153345 | Bolt AM, Byrd RM, Klimecki WT: Autophagy is the predominant process induced by arsenite in human lymphoblastoid cell lines. Toxicol Appl Pharmacol. 2010 Feb 11. We investigated the cytotoxicity of sodium arsenite in LCL 18564 using a set of complementary markers for cell death pathways. |
0(0,0,0,0) | Details |