| Name | cyclin D1 |
|---|---|
| Synonyms | B cell CLL/lymphoma 1; B cell leukemia 1; BCL 1; BCL 1 oncogene; BCL1; CCND 1; CCND1; Cyclin D1… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12426125 | Rossman TG, Uddin AN, Burns FJ, Bosland MC: Arsenite cocarcinogenesis: an animal model derived from genetic toxicology studies. Environ Health Perspect. 2002 Oct;110 Suppl 5:749-52. Rather, low concentrations of arsenite disrupt p53 function and upregulate cyclin D1. Mice were given 10 mg/L sodium arsenite in drinking water (or not) and irradiated with 1.7 KJ/ solar UVR 3 times weekly. |
1(0,0,0,1) | Details |
| 11559025 | Chen H, Liu J, Zhao CQ, Diwan BA, Merrick BA, Waalkes MP: Association of c-myc overexpression and hyperproliferation with arsenite-induced malignant transformation. Toxicol Appl Pharmacol. 2001 Sep 15;175(3):260-8. Consistent with the enhanced proliferation both proliferating cell nuclear antigen and cyclin D1 were overexpressed in CAsE cells. |
1(0,0,0,1) | Details |
| 14691202 | Liu J, Xie Y, Ward JM, Diwan BA, Waalkes MP: Toxicogenomic analysis of aberrant gene expression in liver tumors and nontumorous livers of adult mice exposed in utero to inorganic arsenic. Toxicol Sci. 2004 Feb;77(2):249-57. Epub 2003 Dec 22. Liver tumors and nontumorous liver samples were taken at necropsy from adult male mice exposed in utero to either 42.5 or 85 ppm arsenic as sodium arsenite or unaltered water from day 8 to 18 of gestation. Overexpression of alpha-fetoprotein, c-myc, cyclin D1, proliferation-associated protein PAG, and cytokeratin-18 were more dramatic in arsenic-induced HCC than spontaneous tumors. |
1(0,0,0,1) | Details |
| 14971641 | Xie Y, Liu J, Liu Y, Klaassen CD, Waalkes MP: Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b (-/-) double knockout mice. Mol Cell Biochem. 2004 Jan;255(1-2):11-8. Thus, mdr1a/1b (-/-) and WT mice were exposed to sodium arsenite (0-80 ppm as arsenic) in the drinking water for 10 weeks at which time hepatic arsenic accumulation, lipid peroxidation (LPO), redox status and change in gene expression level were assessed. The expression of cyclin D1, a potential hepatic oncogene, was enhanced in arsenic-exposed mdr1a/1b (-/-) mice only. |
1(0,0,0,1) | Details |
| 19168569 | Andrew AS, Mason RA, Memoli V, Duell EJ: Arsenic activates EGFR pathway signaling in the lung. . Toxicol Sci. 2009 Jun;109(2):350-7. Epub 2009 Jan 23. Downstream of EGFR, arsenic exposure increased pERK and cyclin D1 levels. |
1(0,0,0,1) | Details |
| 17919673 | Arteel GE, Guo L, Schlierf T, Beier JI, Kaiser JP, Chen TS, Liu M, Conklin DJ, Miller HL, von Montfort C, States JC: Subhepatotoxic exposure to arsenic enhances lipopolysaccharide-induced liver injury in mice. Toxicol Appl Pharmacol. 2008 Jan 15;226(2):128-39. Epub 2007 Aug 31. The impairment of proliferation after LPS caused by arsenic was also coupled with alterations in the expression of key mediators of cell cycle progression (p27, p21, CDK6 and Cyclin D1). Male C57Bl/6J mice (4-6 weeks) were exposed to arsenic (49 ppm as sodium arsenite in drinking water). |
1(0,0,0,1) | Details |
| 11578149 | Rossman TG, Uddin AN, Burns FJ, Bosland MC: Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis. Toxicol Appl Pharmacol. 2001 Oct 1;176(1):64-71. Recently we found that low concentrations of arsenite disrupted p53 function and upregulated cyclin D1. Mice given 10 mg/l sodium arsenite in drinking water for 26 weeks had a 2.4-fold increase in yield of tumors after 1.7 KJ/ UVR three times weekly compared with mice given UVR alone. |
1(0,0,0,1) | Details |
| 18191166 | Ahlborn GJ, Nelson GM, Ward WO, Knapp G, Allen JW, Ouyang M, Roop BC, Chen Y, O'Brien T, Kitchin KT, Delker DA: Dose response evaluation of gene expression profiles in the skin of K6/ODC mice exposed to sodium arsenite. Toxicol Appl Pharmacol. 2008 Mar 15;227(3):400-16. Epub 2007 Nov 28. Approximately 20 genes exhibited a dose response, including several genes known to be associated with carcinogenesis or tumor progression including cyclin D1, CLIC4, Ephrin A1, STAT3 and DNA methyltransferase 3a. |
1(0,0,0,1) | Details |
| 11807808 | Kim JY, Choi JA, Kim TH, Yoo YD, Kim JI, Lee YJ, Yoo SY, Cho CK, Lee YS, Lee SJ: Involvement of p38 mitogen-activated protein kinase in the cell growth inhibition by sodium arsenite. J Cell Physiol. 2002 Jan;190(1):29-37. The levels of cyclin D1 expression and the CDK4 kinase activity were also significantly reduced. pRB was hypophosphorylated by sodium arsenite. |
81(1,1,1,1) | Details |
| 17005224 | Hwang BJ, Utti C, Steinberg M: Induction of cyclin D1 by submicromolar concentrations of arsenite in human epidermal keratinocytes. Toxicol Appl Pharmacol. 2006 Dec 1;217(2):161-7. Epub 2006 Aug 11. To gain insight into the oncogenic properties of arsenic, we studied the expression of cyclin D1 in cultured human epidermal keratinocytes treated with submicromolar concentrations of sodium arsenite. |
8(0,0,1,3) | Details |
| 16283521 | Othumpangat S, Kashon M, Joseph P: Sodium arsenite-induced inhibition of eukaryotic translation initiation factor 4E (eIF4E) results in cytotoxicity and cell death. Mol Cell Biochem. 2005 Nov;279(1-2):123-31. Furthermore, exposure of cells to NaAsO2 resulted in a significant inhibition of expression of the cell cycle and growth regulating gene, cyclin D1. |
3(0,0,0,3) | Details |
| 15476864 | Zhou H, Kato A, Yasuda H, Miyaji T, Fujigaki Y, Yamamoto T, Yonemura K, Hishida A: The induction of cell cycle regulatory and DNA repair proteins in cisplatin-induced acute renal failure. Toxicol Appl Pharmacol. 2004 Oct 15;200(2):111-20. The expressions of cyclin-dependent kinase inhibitors (p21 and p27), cyclin B1, cyclin D1, PCNA, GADD 45, and GADD 153 were significantly increased in the outer medulla, reaching peak levels at 3 days after CDDP. Sodium arsenite (SA), a heavy metal, attenuated tubular damage and increased Scr- and TUNEL-positive cells at 5 days after CDDP. |
3(0,0,0,3) | Details |
| 15073043 | Chen H, Li S, Liu J, Diwan BA, Barrett JC, Waalkes MP: Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis. Carcinogenesis. 2004 Sep;25(9):1779-86. Epub 2004 Apr 8. In particular, the expression of the estrogen receptor-alpha (ER-alpha), and cyclin D1 genes were markedly increased. |
2(0,0,0,2) | Details |