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Willemsen P, Scippo ML, Maghuin-Rogister G, Martial JA, Muller M: Enhancement of steroid receptor-mediated transcription for the development of highly responsive bioassays. Anal Bioanal Chem. 2005 Jun;382(4):894-905. Epub 2005 May 20.
Sodium arsenite-induced chemical stress leads to a substantial and specific increase in the glucocorticoid receptor-mediated transcription, resulting in maximal stimulations of more than 2000-fold by the agonist dexamethasone.
Similarly, a combined treatment with forskolin (an activator of adenylate cyclase) and trichostatin A (an inhibitor of histone deacetylases) leads to a synergistic enhancement of progesterone or androgen stimulation, resulting in a maximal induction of more than 200-fold or about 100-fold, respectively. |
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