| Name | CD8 |
|---|---|
| Synonyms | CD8; p32; MAL; CD8A; CD8a antigen; CD8a molecule; LEU2 T lymphocyte antigen; Leu2… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2457504 | Caltabiano MM, Poste G, Greig RG: Isolation and immunological characterization of the mammalian 32-/34-kDa stress protein. Exp Cell Res. 1988 Sep;178(1):31-40. Challenge of mammalian cells with heavy metals or sulfhydryl-reactive agents including sodium arsenite induces the de novo synthesis of a 32-/34-kDa stress protein (p32) (M. |
88(1,1,2,3) | Details |
| 16275621 | Tenorio EP, Saavedra R: Differential effect of sodium arsenite during the activation of human CD4+ and CD8+ T lymphocytes. Int Immunopharmacol. 2005 Dec;5(13-14):1853-69. Epub 2005 Jun 21. |
87(1,1,1,7) | Details |
| 18407307 | Soto-Pena GA, Vega L: Arsenic interferes with the signaling transduction pathway of T cell receptor activation by increasing basal and induced phosphorylation of Lck and Fyn in spleen cells. Toxicol Appl Pharmacol. 2008 Jul 15;230(2):216-26. Epub 2008 Mar 10. Intra-gastric exposure to arsenic (as sodium arsenite) for 30 days (1, 0.1, or 0.01 mg/kg/day), reduced the proportion of CD4+ cells and the CD4+/CD8+ ratio in the spleen, increasing the proportion of CD11b+ cells. |
81(1,1,1,1) | Details |
| 3754488 | Hiwasa T, Sakiyama S: Increase in the synthesis of a Mr 32,000 protein in BALB/c 3T3 cells after treatment with tumor promoters, chemical carcinogens, metal salts, and heat shock. Cancer Res. 1986 May;46(5):2474-81. Among various compounds tested thus far, methyl methanesulfonate, N-methyl-N'-nitro-N-nitrosoguanidine, p-tosyl- chloromethyl ketone, p-tosyl- chloromethyl ketone, 3,3'-diaminobenzidine, and some of the metal salts stimulated the synthesis of p32 to varying extents. p32 might be one of the heat shock proteins because its synthesis was also stimulated by heat shock or sodium arsenite. |
34(0,1,1,4) | Details |
| 3409220 | Kageyama H, Hiwasa T, Tokunaga K, Sakiyama S: Isolation and characterization of a complementary DNA clone for a Mr 32,000 protein which is induced with tumor promoters in BALB/c 3T3 cells. Cancer Res. 1988 Sep 1;48(17):4795-8. The library was constructed from mRNA extracted from the cells treated with sodium arsenite, which stimulates the p32 expression most effectively among various agents so far tested. |
17(0,0,2,7) | Details |
| 3093479 | Caltabiano MM, Koestler TP, Poste G, Greig RG: Induction of 32- and 34-kDa stress proteins by sodium arsenite, heavy metals, and thiol-reactive agents. J Biol Chem. 1986 Oct 5;261(28):13381-6. Enhanced expression of the 32- and 34-kDa polypeptides (p32 and p34) preceded or paralleled the synthesis of the other stress proteins. |
4(0,0,0,4) | Details |
| 15147786 | Vega L, Montes de Oca P, Saavedra R, Ostrosky-Wegman P: Helper T cell subpopulations from women are more susceptible to the toxic effect of sodium arsenite in vitro. Toxicology. 2004 Jul 1;199(2-3):121-8. Arsenic susceptibility of lymphocyte subpopulations (T helper (Th), CD4+; T cytotoxic (Tc), CD8+) and whether arsenic effects are gender related are still to be determined. |
1(0,0,0,1) | Details |
| 17009048 | Conde P, Acosta-Saavedra LC, Goytia-Acevedo RC, Calderon-Aranda ES: Sodium arsenite-induced inhibition of cell proliferation is related to inhibition of IL-2 mRNA expression in mouse activated T cells. Arch Toxicol. 2007 Apr;81(4):251-9. Epub 2006 Sep 29. Arsenite also decreased early activation (surface CD69+ expression) in both CD4+ and CD8+, and decreased total CD8+ count without significantly affecting CD4+, supporting that the cellular immune response mediated by cytotoxic T cells is an arsenic target. |
1(0,0,0,1) | Details |
| 7772027 | Rossi A, Santoro MG: Induction by of haem oxygenase in myoblastic cells: an effect independent of expression of the 70 kDa heat shock protein. Biochem J. 1995 Jun 1;308 ( Pt 2):455-63. The p32 protein has been identified as haem oxygenase. |
1(0,0,0,1) | Details |
| 8228242 | Tamura Y, Tsuboi N, Sato N, Kikuchi K: 70 kDa heat shock cognate protein is a transformation-associated antigen and a possible target for the host's anti-tumor immunity. J Immunol. 1993 Nov 15;151(10):5516-24. The accumulated data indicated that the cell surface expression of Ag was clearly enhanced by several stressors, such as TNF, L-azetidine-2-carboxylic acid, and sodium arsenite. |
0(0,0,0,0) | Details |