| Name | heat shock protein 72 |
|---|---|
| Synonyms | HSP70 1; HSP72; HSPA 1; HSPA1; HSPA1A; HSPA1B; Heat shock 70 KD protein 1A; Heat shock 70KD protein 1… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12842450 | Carter Y, Liu G, Stephens WB, Carter G, Yang J, Mendez C: Heat shock protein (HSP72) and p38 MAPK involvement in sublethal hemorrhage (SLH)-induced tolerance. J Surg Res. 2003 May 1;111(1):70-7. This study investigated if SLH induces in vivo HSP72 expression and whether in vitro HSP72 induction by sodium arsenite (NaArs) alters intracellular signal transduction and cytokine production similar to SLH. |
39(0,1,1,9) | Details |
| 2002259 | Edwards MJ, Marks R, Dykes PJ, Merrett VR, Morgan HE, O'Donovan MR: Heat shock proteins in cultured human keratinocytes and fibroblasts. . J Invest Dermatol. 1991 Mar;96(3):392-6. Exposure of these cells to weak inducing agents such as heat or cadmium sulphate resulted in the synthesis of HSP72 and HSP90, whereas HSP28 and HSP116 synthesis was detected in keratinocytes and fibroblasts following exposure to the strong inducing agent sodium arsenite. |
32(0,1,1,2) | Details |
| 9176145 | Wang JH, Redmond HP, Watson RW, Bouchier-Hayes D: Induction of human endothelial cell apoptosis requires both heat shock and oxidative stress responses. Am J Physiol. 1997 May;272(5 Pt 1):C1543-51. Sodium arsenite at 80-320 microM, which induced heat shock protein 72 (HSP72) expression and reactive intermediate (ROI) generation in ECs, resulted in EC apoptosis. |
12(0,0,2,2) | Details |
| 9820195 | Dix DJ, Garges JB, Hong RL: Inhibition of hsp70-1 and hsp70-3 expression disrupts preimplantation embryogenesis and heightens embryo sensitivity to arsenic. Mol Reprod Dev. 1998 Dec;51(4):373-80. Limiting expression of Hsp70-1/3 with 5 microM A070-1/3 also heightened embryo sensitivity to arsenic, resulting in less than 5% in vitro development to blastocyst in the presence of the subtoxic dose of 0.4 microM sodium arsenite. |
12(0,0,1,7) | Details |
| 8433029 | Kampinga HH, Muller E, Brunsting JF, Heine L, Konings AW, Issels RD: Association of HSP72 with the nuclear (TX-100-insoluble) fraction upon heating tolerant and non-tolerant HeLa S3 cells. Int J Hyperthermia. 1993 Jan-Feb;9(1):89-98. HSP72 levels in the cellular and the nuclear (TX-insoluble) fraction before and after heating of heat- and sodium arsenite-induced thermotolerant and non-tolerant HeLa S3 cells have been investigated by 1D- and 2D-electrophoresis, followed by Western blotting and immunostaining, using a newly developed monoclonal antibody that specifically detects HSP72 (Heine et al. 1991). |
10(0,0,1,5) | Details |
| 8647995 | Muramatsu T, Kobayashi N, Tada H, Hatoko M, Shirai T: Induction of the 72-kD heat shock protein in human skin melanoma and squamous cell carcinoma cell lines. J Dermatol. 1995 Dec;22(12):907-12. In the present study, we examined the effects of heat, chemicals (azetidine and sodium arsenite), ultraviolet (UV) light, and gamma-ray irradiation on the induction of HSP72 in cultured human skin melanoma cell lines (P-39 and G-361), a human skin squamous cell carcinoma cell line (HSC-1), and an SV40-transformed human lung fibroblast cell line (WI38VA13) as a control. |
10(0,0,1,5) | Details |
| 12690470 | Zhou H, Kato A, Yasuda H, Odamaki M, Itoh H, Hishida A: The induction of heat shock protein-72 attenuates cisplatin-induced acute renal failure in rats. Pflugers Arch. 2003 Apr;446(1):116-24. Epub 2003 Feb 15. Uranyl (UA) or sodium arsenite (SA) were administered i.v. 14 days or 1 day respectively before CDDP injection to induce HSPs. |
8(0,0,0,8) | Details |
| 10896383 | Pritts TA, Wang Q, Sun X, Moon MR, Fischer DR, Fischer JE, Wong HR, Hasselgren PO: Induction of the stress response in vivo decreases nuclear factor-kappa B activity in jejunal mucosa of endotoxemic mice. Arch Surg. 2000 Jul;135(7):860-6. RESULTS: Mucosal levels of heat shock protein-72 increased after hyperthermia or treatment with sodium arsenite, consistent with induction of the stress response. |
6(0,0,1,1) | Details |
| 7794296 | Ribeiro SP, Villar J, Downey GP, Edelson JD, Slutsky AS: Sodium arsenite induces heat shock protein-72 kilodalton expression in the lungs and protects rats against sepsis. Crit Care Med. 1994 Jun;22(6):922-9. |
6(0,0,1,1) | Details |
| 12095131 | Pritts TA, Wang Q, Sun X, Fischer DR, Hungness ES, Fischer JE, Wong HR, Hasselgren PO: The stress response decreases NF-kappaB activation in liver of endotoxemic mice. Shock. 2002 Jul;18(1):33-7. The stress response was induced in mice by hyperthermia (42 degrees C for 3 min) or sodium arsenite (10 mg/kg) and resulted in increased hepatic heat shock protein-72 levels. |
6(0,0,1,1) | Details |
| 9756346 | Yang YL, Lu KT, Tsay HJ, Lin CH, Lin MT: Heat shock protein expression protects against death following exposure to heatstroke in rats. Neurosci Lett. 1998 Aug 7;252(1):9-12. Rats 0, 16, or 48 h after heat shock (42 degrees C core temperature for 15 min) or chemical stress (5 mg/kg sodium arsenite, i.p.) were exposed to a high ambient temperature (43 degrees C) to induce heatstroke onset. Prior heat shock or chemical stress conferred significant protection against heatstroke-induced arterial hypotension, cerebral ischemia, cerebral neuronal damage and death, and correlated with expression of HSP72 in brain, heart, liver and kidney at 16 h. |
3(0,0,0,3) | Details |
| 1764242 | Lowenstein DH, Chan PH, Miles MF: The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicity. Neuron. 1991 Dec;7(6):1053-60. Initial experiments used one- and two-dimensional polyacrylamide gel electrophoresis to confirm the induction of typical stress protein size classes by heat shock, sodium arsenite, and the ionophore A23187. Immunoblot analysis and immunocytochemistry verified the expression of the highly inducible 72 kd heat shock protein (HSP72). |
1(0,0,0,1) | Details |
| 11893605 | Pritts TA, Hungness ES, Hershko DD, Robb BW, Sun X, Luo GJ, Fischer JE, Wong HR, Hasselgren PO: Proteasome inhibitors induce heat shock response and increase IL-6 expression in human intestinal epithelial cells. Am J Physiol Regul Integr Comp Physiol. 2002 Apr;282(4):R1016-26. In previous studies, the heat shock response, induced by hyperthermia or sodium arsenite, increased interleukin (IL)-6 production in intestinal mucosa and cultured human enterocytes. Treatment of Caco-2 cells with one of the proteasome inhibitors MG-132 or lactacystin activated the transcription factor heat shock factors (HSF)-1 and -2 and upregulated cellular levels of the 72-kDa heat shock protein HSP-72. |
1(0,0,0,1) | Details |
| 11832385 | Wang Q, Hasselgren PO: Heat shock response reduces intestinal permeability in septic mice: potential role of interleukin-10. Am J Physiol Regul Integr Comp Physiol. 2002 Mar;282(3):R669-76. The heat shock response was induced in mice by intraperitoneal injection of 10 mg/kg sodium arsenite. Two hours later, at which time mucosal heat shock protein 72 levels were increased, sepsis was induced by cecal ligation and puncture (CLP) or sham operation was performed. |
1(0,0,0,1) | Details |
| 15733543 | Ialenti A, Di Meglio P, D'Acquisto F, Pisano B, Maffia P, Grassia G, Di Rosa M, Ianaro A: Inhibition of cyclooxygenase-2 gene expression by the heat shock response in J774 murine macrophages. Eur J Pharmacol. 2005 Feb 21;509(2-3):89-96. The heat shock response is a highly conserved mechanism of protection elicited in the cell by various kinds of stimuli, such as heat, sodium arsenite, oxidants and inflammation. Such a reduction was associated to activation of heat shock factor, increased levels of heat shock protein 72 and inhibition of lipopolysaccharide-induced nuclear factor-kappaB binding activity. |
1(0,0,0,1) | Details |
| 12141822 | Rakonczay Z Jr, Mandi Y, Kaszaki J, Ivanyi B, Boros I, Lonovics J, Takacs T: Induction of HSP72 by sodium arsenite fails to protect against cholecystokinin-octapeptide-induced acute pancreatitis in rats. Dig Dis Sci. 2002 Jul;47(7):1594-603. A number of investigators have demonstrated that the preinduction of heat-shock protein (HSP) expression (particularly HSP60 and HSP72) by hyper- or hypothermia may have a protective effect against cerulein-induced acute pancreatitis. |
1(0,0,0,1) | Details |
| 12489113 | Barnes JA, Collins BW, Dix DJ, Allen JW: Effects of heat shock protein 70 (Hsp70) on arsenite-induced genotoxicity. . Environ Mol Mutagen. 2002;40(4):236-42. Human MCF-7 Tet-off cells stably transfected with a pTRE/Hsp70-1 transgene construct were used to regulate Hsp70 levels prior to in vitro As exposures. |
1(0,0,0,1) | Details |
| 10362676 | Yang YL, Lin MT: Heat shock protein expression protects against cerebral ischemia and monoamine overload in rat heatstroke. Am J Physiol. 1999 Jun;276(6 Pt 2):H1961-7. This study attempted to ascertain whether the ischemic damage to neurons and monoamine overload in brain that occur during rat heatstroke can be attenuated by heat shock protein (HSP) 72 induction. Effects of heatstroke on mean arterial pressure (MAP), cerebral blood flow (CBF), brain (DA) and release, and neural damage score were assayed in rats 0, 16, or 48 h after heat shock (42 degrees C for 15 min) or chemical stress (5 mg/kg sodium arsenite ip). |
1(0,0,0,1) | Details |
| 8016744 | Mirkes PE, Doggett B, Cornel L: Induction of a heat shock response (HSP 72) in rat embryos exposed to selected chemical teratogens. Teratology. 1994 Feb;49(2):135-42. A monoclonal antibody to the 72 kD heat shock protein (HSP 72), Western blot analysis and 2-D gel electrophoresis/autoradiography were used to determine whether selected chemical teratogens induced the synthesis and accumulation of HSP 72 in postimplantation rat embryos exposed in vitro. |
1(0,0,0,1) | Details |
| 7492272 | Wang JH, Redmond HP, Watson RW, Condron C, Bouchier-Hayes D: Induction of heat shock protein 72 prevents neutrophil-mediated human endothelial cell necrosis. Arch Surg. 1995 Dec;130(12):1260-5. OBJECTIVE: To examine the hypothesis that induction of heat shock proteins in human endothelial cells (ECs) by either heat shock or sodium arsenite could prevent subsequent EC necrosis induced by activated human polymorphonuclear neutrophil leukocytes (PMNs). |
1(0,0,0,1) | Details |
| 12388181 | Harada T, Koyama I, Kasahara T, Alpers DH, Komoda T: Heat shock induces intestinal-type alkaline phosphatase in rat IEC-18 cells. Am J Physiol Gastrointest Liver Physiol. 2003 Feb;284(2):G255-62. Epub 2002 Oct 16. IAP-I was also induced by sodium arsenite, which generates reactive species and is an inducer of members of the HSP family. |
0(0,0,0,0) | Details |