Protein Information

Name TNFalpha
Synonyms Cachectin; DIF; TNF; TNF alpha; TNF a; TNFA; TNFSF 2; TNFSF2…

Compound Information

Name lindane
CAS (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane

Reference List

PubMed Abstract RScore(About this table)
15019085 Valencia C, Cornejo P, Romanque P, Tapia G, Varela P, Videla LA, Fernandez V: Effects of acute lindane intoxication and thyroid hormone administration in relation to nuclear factor-kappaB activation, tumor necrosis factor-alpha expression, and Kupffer cell function in the rat. Toxicol Lett. 2004 Mar 14;148(1-2):21-8.
112(1,2,2,2) Details
18757214 Cuesta A, Meseguer J, Angeles Esteban M: Effects of the organochlorines p,p'-DDE and lindane on gilthead seabream leucocyte immune parameters and gene expression. Fish Shellfish Immunol. 2008 Nov;25(5):682-8. Epub 2008 Feb 16.

However, both p,p'-DDE and lindane up-regulated to varying degrees some immune-related genes such as IL-1beta, TNFalpha, MHCIalpha, MHCIIalpha, Mx, TLR9, IgML and TCRalpha.
6(0,0,1,1) Details
15025948 Videla LA, Tapia G, Varela P, Cornejo P, Guerrero J, Israel Y, Fernandez V: Effects of acute gamma-hexachlorocyclohexane intoxication in relation to the redox regulation of nuclear factor-kappaB, cytokine gene expression, and liver injury in the rat. Antioxid Redox Signal. 2004 Apr;6(2):471-80.


Liver NF-kappaB activation (electrophoretic mobility shift assay), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1alpha (IL-1alpha) mRNA expression (reverse transcription-polymerase chain reaction), and their serum levels (enzyme-linked immunosorbent assay) were measured at different times after gamma-hexachlorocyclohexane treatment (50 mg/kg).
1(0,0,0,1) Details