Protein Information

Name thyroperoxidase
Synonyms MSA; TPO; TPO protein; TPX; Thyroid microsomal antigen; Thyroid peroxidase; Thyroid peroxidase isoform d variant; Thyroid peroxidase precursor…

Compound Information

Name acetochlor
CAS

Reference List

PubMed Abstract RScore(About this table)
9681970 Hurley PM: Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Environ Health Perspect. 1998 Aug;106(8):437-45.

Intrathyroidal and extrathyroidal sites of action are found: amitrole, ethylene thiourea, and mancozeb are thyroid peroxidase inhibitors; and acetochlor, clofentezine, fenbuconazole, fipronil, pendimethalin, pentachloronitrobenzene, prodiamine, pyrimethanil, and thiazopyr seem to enhance the hepatic metabolism and excretion of thyroid hormone.
31(0,1,1,1) Details
17651757 Roman GC: Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents. J Neurol Sci. 2007 Nov 15;262(1-2):15-26. Epub 2007 Jul 24.

Genistein and daidzein from soy (Glycine max) inhibit thyroperoxidase that catalyzes iodination and thyroid hormone biosynthesis.
Environmental contaminants interfere with thyroid function including 60% of all herbicides, in particular 2,4-dichlorophenoxyacetic acid (2,4-D), acetochlor, aminotriazole, amitrole, bromoxynil, pendamethalin, mancozeb, and thioureas.
2(0,0,0,2) Details