| Name | glutathione S transferases |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | MCPA |
|---|---|
| CAS | 2-(4-chloro-2-methylphenoxy)acetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1852715 | Santagostino A, Leone MP, Maci R, Casale A, Marabini L: Effects of phenoxyacetic acid herbicides on chicken embryo liver drug metabolizing enzymes. Pharmacol Toxicol. 1991 Feb;68(2):110-4. The higher dose of MCPA increased NADPH-cytochrome P450 reductase. 2,4-D treatment increased by activity of glutathione-S-transferases in the hepatic post-microsomal fraction while MCPA increased them at the lower dose and significantly reduced them at the higher. |
31(0,1,1,1) | Details |
| 2813285 | Santagostino A, Colleoni M, Arias E, Pacces Zaffaroni N, Zavanella T: Changes in catalase, peroxidase and glutathione-S-transferase activities in the liver of newts exposed to 2-methyl-4-chlorophenoxyacetic acid (MCPA). Pharmacol Toxicol. 1989 Aug;65(2):136-9. |
12(0,0,2,2) | Details |
| 9580876 | Holovska K, Lenartova V, Rosival I, Kicinkova M, Majerciakova A, Legath J: Antioxidant and detoxifying enzymes in the liver and kidney of pheasants after intoxication by herbicides MCPA and ANITEN I. J Biochem Mol Toxicol. 1998;12(4):235-44. The activity of antioxidant and detoxifying enzymes, such as superoxide dismutase (SOD), catalase (CAT), peroxidase (GSHPx), glutathione reductase, glutathione-S-transferase (GST), the contents of thiobarbituric acid reactive substances, and the superoxide dismutase and glutathione-S-transferase isoenzyme patterns, were determined in the liver and kidney of pheasants after acute intoxication by herbicides MCPA and ANITEN I. |
8(0,0,1,3) | Details |
| 6624478 | Hietanen E, Linnainmaa K, Vainio H: Effects of phenoxyherbicides and on the hepatic and intestinal biotransformation activities in the rat. Acta Pharmacol Toxicol. 1983 Aug;53(2):103-12. Both 2,4-D and MCPA increased the hepatic epoxide hydrolase activity and decreased the hepatic glutathione S-transferase activity. |
6(0,0,1,1) | Details |
| 3969683 | Hietanen E, Ahotupa M, Heinonen T, Hamalainen H, Kunnas T, Linnainmaa K, Mantyla E, Vainio H: Enhanced peroxisomal beta-oxidation of fatty acids and glutathione metabolism in rats exposed to phenoxyacetic acids. Toxicology. 1985 Feb;34(2):103-11. Peroxisomal beta-oxidation of fatty acids and the activities of -metabolizing enzymes in rat liver were measured after administration of 2,4-dichlorophenoxyacetic acid (2,4-D), 4-chloro-2-methylphenoxyacetic acid (MCPA), clofibrate [ethyl], 2-(p-chlorophenoxy)- (N-phosphonomethyl a herbicide not structurally related to phenoxy acids) or saline for 14 days. beta-Oxidation increased by 6-fold in the group given clofibrate, 3-fold in the 2,4-D-treated group, and 2-fold in the MCPA-treated group over the level in the controls (saline-treated). A slight decrease in glutathione S-transferase activity was found in the group treated with clofibrate. |
1(0,0,0,1) | Details |