Protein Information

Name glutathione transferase
Synonyms GST class mu 2; GST 4; GST4; GSTM; GSTM 2; GSTM2; GSTM2 2; GSTmu3…

Compound Information

Name fluorodifen
CAS 2-nitro-1-(4-nitrophenoxy)-4-(trifluoromethyl)benzene

Reference List

PubMed Abstract RScore(About this table)
9484464 Dixon DP, Cole DJ, Edwards R: Purification, regulation and cloning of a glutathione transferase (GST) from maize resembling the auxin-inducible type-III GSTs. Plant Mol Biol. 1998 Jan;36(1):75-87.

The glutathione transferases (GSTs) from maize (Zea mays L.) with activities toward the chloroacetanilide herbicide metolachlor and the diphenyl ether herbicide fluorodifen were fractionated into two pools based on binding to affinity columns.
32(0,1,1,2) Details
12692133 Dixon DP, McEwen AG, Lapthorn AJ, Edwards R: Forced evolution of a herbicide detoxifying glutathione transferase. . J Biol Chem. 2003 Jun 27;278(26):23930-5. Epub 2003 Apr 11.

Plant Tau class glutathione transferases (GSTUs) detoxify diphenylether herbicides such as fluorodifen, determining their selectivity in crops and weeds.
7(0,0,1,2) Details
9224692 Skipsey M, Andrews CJ, Townson JK, Jepson I, Edwards R: Substrate and thiol specificity of a stress-inducible glutathione transferase from soybean. FEBS Lett. 1997 Jun 16;409(3):370-4.

No thiol preference was shown with the related herbicide, fluorodifen, while GSH was preferred with metolachlor and most non-herbicide substrates.
2(0,0,0,2) Details
7725348 Di Ilio C, Sacchetta P, Iannarelli V, Aceto A: Binding of pesticides to alpha, mu and pi class glutathione transferase. . Toxicol Lett. 1995 Mar;76(2):173-7.

The binding of fluorodifen, fenarimol, acifluorfen, 2,4-DES, methyl parathion, paraquat and pyrazophos by alpha, mu and pi class glutathione transferases (GST) was determined by the 2-p-toluidinylnaphthalene-6-sulphonate (TNS) binding fluorescence inhibition technique.
32(0,1,1,2) Details
19462193 Schroder P, Lyubenova L, Huber C: Do heavy metals and metalloids influence the detoxification of organic xenobiotics in plants?. Environ Sci Pollut Res Int. 2009 Nov;16(7):795-804. Epub 2009 May 22.

Enzymes of interest for the present study were: glutathione transferase (GST), glutathione reductase, ascorbate peroxidase and peroxidase.
GST spectrophotometric assays included the model substrates CDNB, DCNB, NBC, NBoC and the herbicide Fluorodifen.
1(0,0,0,1) Details
19014949 Axarli I, Dhavala P, Papageorgiou AC, Labrou NE: Crystallographic and functional characterization of the fluorodifen-inducible glutathione transferase from Glycine max reveals an active site topography suited for diphenylether herbicides and a novel L-site. J Mol Biol. 2009 Jan 23;385(3):984-1002. Epub 2008 Nov 6.
7(0,0,1,2) Details