Protein Information

Name HDAC4
Synonyms HA6116; HD4; HDAC 4; HDAC A; HDAC4; HDACA; Histone deacetylase 4; Histone deacetylase A…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
17610967 Glenisson W, Castronovo V, Waltregny D: Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation. Biochim Biophys Acta. 2007 Oct;1773(10):1572-82. Epub 2007 Jun 12.

4(0,0,0,4) Details
19700647 Guo W, Shan B, Klingsberg RC, Qin X, Lasky JA: Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L864-70. Epub 2009 Aug 21.


HDAC4 knockdown was effective in inhibiting TGF-beta1-stimulated alpha-SMA expression as well as the phosphorylation of Akt.
2(0,0,0,2) Details