Protein Information

Name immunoglobulins (protein family or complex)
Synonyms Immunoglobulin; Immunoglobulins

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19230171 Stangou M, Alexopoulos E, Pantzaki A, Leonstini M, Memmos D: C5b-9 glomerular deposition and tubular alpha3beta1-integrin expression are implicated in the development of chronic lesions and predict renal function outcome in immunoglobulin A nephropathy. Scand J Urol Nephrol. 2008;42(4):373-80.

2(0,0,0,2) Details
19768664 Mukherjee S, Pondaven SP, Hofer N, Jaroniec CP: Backbone and side-chain (1) H, (13) C and (15) N resonance assignments of LEN, a human immunoglobulin kappaIV light-chain variable domain. Biomol NMR Assign. 2009 Dec;3(2):255-9.

(1) H, (13) C and (15) N resonance assignments are presented for a recombinant 114 amino acid human immunoglobulin (Ig) kappaIV light-chain variable domain (VL) LEN, which displays a high degree of sequence identity with another human Ig kappaIV VL, SMA.
7(0,0,1,2) Details
18609274 Stangou M, Alexopoulos E, Pantzaki A, Leonstini M, Memmos D: C5b-9 glomerular deposition and tubular alpha (3) beta (1)-integrin expression are implicated in the development of chronic lesions and predict renal function outcome in immunoglobulin A nephropathy. Scand J Urol Nephrol. 2008 Feb 21:1-8.

2(0,0,0,2) Details
18691595 Martinez-Neira R, dos Remedios CG, Mackay IR: An actin-myosin functional assay for analysis of smooth muscle (anti-microfilament) autoantibodies in human plasma. J Immunol Methods. 2008 Sep 30;338(1-2):63-6. Epub 2008 Aug 6.


Using an in vitro functional assay, we compared the effects of Fab fragments of immunoglobulin (IgG) prepared from SMA-positive plasma from two patients with the effects of Fabs from 10 healthy subjects.
1(0,0,0,1) Details
19514352 Kogan EA, Tyong FV, Demura SA: [Molecular bases for the development of variants of idiopathic fibrosing alveolitis]. Arkh Patol. 2009 Jan-Feb;71(1):12-8.


Biotin-conjugated antibodies to murine and rabbit immunoglobulins (Dako LSAB + KIT, PEROXIDASE) were used as secondary antibodies.
1(0,0,0,1) Details
18619464 Meng X, Fink AL, Uversky VN: The effect of membranes on the in vitro fibrillation of an amyloidogenic light-chain variable-domain SMA. J Mol Biol. 2008 Sep 12;381(4):989-99. Epub 2008 Jun 28.


Light chain (or AL) amyloidosis is the most common form of systemic amyloidosis, characterized by the pathological deposition of insoluble fibrils of immunoglobulin light-chain fragments in various organs and tissues, especially in the kidney and heart.
1(0,0,0,1) Details
17621360 Jaskowski TD, Konnick EQ, Ashwood ER, Litwin CM, Hill HR: Prevalence of IgG autoantibody against F-actin in patients suspected of having autoimmune or acute viral hepatitis. J Clin Lab Anal. 2007;21(4):249-53.


Our objectives in this study were to compare results obtained by an enzyme immunoassay (EIA) for F-actin antibody (FAA) immunoglobulin G (IgG) to those determined by an indirect fluorescent antibody (IFA) assay for smooth muscle antibody (SMA) IgG, and to determine the prevalence of FAA in patient sera having serologic evidence of acute viral hepatitis.
1(0,0,0,1) Details
18260767 Dobano C, Rogerson SJ, Mackinnon MJ, Cavanagh DR, Taylor TE, Molyneux ME, McBride JS: Differential antibody responses to Plasmodium falciparum merozoite proteins in Malawian children with severe malaria. J Infect Dis. 2008 Mar 1;197(5):766-74.


Children with SMA were distinguished by very low levels of immunoglobulin (Ig) G to the conserved C-terminus of MSP-1 and MSP-2 and to full-length AMA-1.
1(0,0,0,1) Details
18641694 Du Q, Chen Z, Zhou LF, Zhang Q, Huang M, Yin KS: Inhibitory effects of astragaloside IV on ovalbumin-induced chronic experimental asthma. Can J Physiol Pharmacol. 2008 Jul;86(7):449-57.


Astragaloside IV treatment resulted in significant reduction of eosinophilic airway inflammation, airway hyperresponsiveness, interleukin (IL)-4 and IL-13 levels in bronchoalveolar lavage fluid, and total immunoglobulin E levels in serum.
1(0,0,0,1) Details
19676002 Mieli-Vergani G, Vergani D: Autoimmune hepatitis in children: what is different from adult AIH? . Semin Liver Dis. 2009 Aug;29(3):297-306. Epub 2009 Aug 12.


Autoimmune hepatitis (AIH) is characterized by inflammatory liver histology, circulating non-organ-specific autoantibodies, and increased levels of immunoglobulin (Ig) G in the absence of a known etiology.
1(0,0,0,1) Details
18274981 Tourkantoni N, Athanassiou-Metaxa M, Zafiriou D, Tzimouli V, Economou M, Taparkou A, Perifanis V, Kanakoudi-Tsakalidou F: Immune and neural status of thalassemic patients receiving deferiprone or combined deferiprone and deferoxamine chelation treatment. Hemoglobin. 2008;32(1-2):35-40.


The immune and neural status of 44 beta-thalassemic patients, aged 10-30 years (mean 19.4 +/- 4.9), receiving L1 as a monotherapy (n = 21), or in combination with DFO (n = 23), has been followed for 2 years by monitoring the level of immunoglobulins (IgG, IgM, IgA), the level of T and B lymphocytes (CD4/CD8), the auto antibodies: anti nuclear (ANA), anti-double-stranded (anti-ds DNA), anti reticulin (anti-R1), anti-extra nuclear (anti-ENA), anti histone (anti-AHA), anti liver-kidney-muscle (anti-LKM), anti-smooth muscle (anti-SMA), anti-thyroid (anti-ATA), anti-mitochondrial (anti-AMA) antibodies and the C-reactive protein.
1(0,0,0,1) Details