Protein Information

Name endothelial nitric oxide synthase
Synonyms Constitutive NOS; NOS 3; NOS3; EC NOS; ECNOS; ENOS; Endothelial NOS; Endothelial nitric oxidase synthase…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19473465 Becher EF, Toblli JE, Castronuovo C, Nolazco C, Rosenfeld C, Grosman H, Vazquez E, Mazza ON: Expression of caveolin-1 in penile cavernosal tissue in a denervated animal model after treatment with sildenafil citrate. J Sex Med. 2009 Jun;6(6):1587-93. Epub 2009 Mar 30.


Endothelial nitric oxide synthase, which generates nitric oxide (NO) in the cavernosal tissues, localizes to specialized plasma membrane invaginations known as caveolae.
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17888071 Toblli JE, Cao G, Casabe AR, Bechara AJ: Effects of ACE inhibition and beta-blockade on female genital structures in spontaneously hypertensive rats. J Sex Med. 2007 Nov;4(6):1593-603. Epub 2007 Sep 21.


Clitorises were processed for immunohistochemistry using anti-alpha-smooth muscle actin (alpha-SMA), anti-collagen I and III, anti-transforming growth factor beta (1) (TGFbeta (1)), and anti-endothelial nitric oxide synthase (eNOS) antibodies.
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19572028 Huber LC, Soltermann A, Fischler M, Gay S, Weder W, Russi EW, Speich R, Ulrich S: Caveolin-1 Expression and Hemodynamics in COPD Patients. Open Respir Med J. 2009 May 13;3:73-8.


Caveolin-1 is a regulator of both intracellular calcium homeostasis and endothelial nitric oxide synthase and may play a pathogenetic role in pulmonary hypertension.
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19683567 Xu X, Kherada N, Hong X, Quan C, Zheng L, Wang A, Wold LE, Lippmann M, Chen LC, Rajagopalan S, Sun Q: Diesel exhaust exposure induces angiogenesis. Toxicol Lett. 2009 Dec 1;191(1):57-68. Epub 2009 Aug 14.


WDE exposure led to increased CD31 expression, while decreasing endothelial nitric oxide synthase in the aortic wall.
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18031380 Malyshev E, Tazi KA, Moreau R, Lebrec D: Discrepant effects of inducible nitric oxide synthase modulation on systemic and splanchnic endothelial nitric oxide synthase activity and expression in cirrhotic rats. J Gastroenterol Hepatol. 2007 Dec;22(12):2195-201.

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20232302 Roson MI, Della Penna SL, Cao G, Gorzalczany S, Pandolfo M, Toblli JE, Fernandez BE: Different protective actions of losartan and tempol on the renal inflammatory response to acute sodium overload. J Cell Physiol. 2010 Mar 15.


Ang II, NF-kappaB, hypoxia inducible factor-1alpha (HIF-1alpha), transforming growth factor beta1 (TGF-beta1), smooth muscle actin (alpha-SMA), endothelial nitric oxide synthase (eNOS), and RANTES renal expression was evaluated by immunohistochemistry.
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