Protein Information

Name follistatin
Synonyms Activin binding protein; FS; FST; Follistatin; Follistatin precursor; Follistatins; Follistatin precursors

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
17576240 Fumagalli M, Musso T, Vermi W, Scutera S, Daniele R, Alotto D, Cambieri I, Ostorero A, Gentili F, Caposio P, Zucca M, Sozzani S, Stella M, Castagnoli C: Imbalance between activin A and follistatin drives postburn hypertrophic scar formation in human skin. Exp Dermatol. 2007 Jul;16(7):600-10.

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19074460 Rose FF Jr, Mattis VB, Rindt H, Lorson CL: Delivery of recombinant follistatin lessens disease severity in a mouse model of spinal muscular atrophy. Hum Mol Genet. 2009 Mar 15;18(6):997-1005. Epub 2008 Dec 12.

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19477958 Sumner CJ, Wee CD, Warsing LC, Choe DW, Ng AS, Lutz C, Wagner KR: Inhibition of myostatin does not ameliorate disease features of severe spinal muscular atrophy mice. Hum Mol Genet. 2009 Sep 1;18(17):3145-52. Epub 2009 May 28.


In this study, we evaluated the effects of blocking myostatin signaling in severe SMA mice (hSMN2/delta7SMN/mSmn (-/-)) by two independent strategies: (i) transgenic overexpression of the myostatin inhibitor follistatin and (ii) post-natal administration of a soluble activin receptor IIB (ActRIIB-Fc).
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20233786 Corpuz PS, Lindaman LL, Mellon PL, Coss D: FoxL2 Is Required for Activin Induction of the Mouse and Human Follicle-Stimulating Hormone {beta}-Subunit Genes. Mol Endocrinol. 2010 Mar 16.


We identify FoxL2 as a critical component in activin induction of FSHbeta, both for the mouse gene, induction of which is Sma- and Mad-related protein (Smad) dependent, and for the human gene that is Smad independent.
0(0,0,0,0) Details