Protein Information

Name Sca 1
Synonyms Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
17711723 Wu Y, Wang LY, Zhang HX, Chen D, Wang W, Xiao L, Fang W, Wang F, Shang JF: [Effects of the total flavone of radix puerariae on apoptotic cell and apoptotic related-gene in atherosclerotic plaques of apoE gene deficiency mice]. Zhonghua Xin Xue Guan Bing Za Zhi. 2007 Jun;35(6):567-70.


The expression of CD-68, SMA and Caspase-3 were determined by immunochemical methods.
3(0,0,0,3) Details
17708838 Hu S, Zou XF, Lu Y, Lu JY, Sheng ZY: [Effects of carbachol on apoptosis of intestinal epithelial cells after gut ischemia/reperfusion in rat]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2007 Aug;19(8):463-6.


Expressions of caspase-3 and Bcl-2 in intestinal epithelial cells were assayed by immunohistochemistry method.
2(0,0,0,2) Details
18367439 Parker GC, Li X, Anguelov RA, Toth G, Cristescu A, Acsadi G: Survival motor neuron protein regulates apoptosis in an in vitro model of spinal muscular atrophy. Neurotox Res. 2008 Jan;13(1):39-48.


Smn-depleted cells showed elevated caspase-3 activity, decreased cell viability and increased percentage of TUNEL positive cells.
2(0,0,0,2) Details
19583956 Pot SA, Chandler HL, Colitz CM, Bentley E, Dubielzig RR, Mosley TS, Reid TW, Murphy CJ: Selenium functionalized intraocular lenses inhibit posterior capsule opacification in an ex vivo canine lens capsular bag assay. Exp Eye Res. 2009 Nov;89(5):728-34. Epub 2009 Jul 5.


Proliferating cell nuclear antigen (PCNA), alpha-smooth muscle actin (alpha-SMA) and cleaved caspase-3 were examined by immunohistochemistry.
1(0,0,0,1) Details
18224284 Lopez V, Keen CL, Lanoue L: Prenatal zinc deficiency: influence on heart morphology and distribution of key heart proteins in a rat model. Biol Trace Elem Res. 2008 Jun;122(3):238-55. Epub 2008 Jan 26.


Fetuses were collected on GD 13.5, 15.5, and 18.5 and processed for GATA-4, FOG-2, connexin-43 (Cx43), HNK-1, smooth muscle alpha-actin (SMA) and cleaved caspase-3 protein expression.
1(0,0,0,1) Details
19114984 Liu Y, Lui EL, Friedman SL, Li L, Ye T, Chen Y, Poon RT, Wo J, Kok TW, Fan ST: PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling. Lab Invest. 2009 Feb;89(2):209-21. Epub 2008 Dec 29.


PTK/ZK-induced apoptosis of HSCs, which was correlated with increased caspase-3 activation and suppressed Bcl-2 expression.
1(0,0,0,1) Details
19597127 Lepparanta O, Pulkkinen V, Koli K, Vahatalo R, Salmenkivi K, Kinnula VL, Heikinheimo M, Myllarniemi M: Transcription Factor GATA-6 is Expressed in Quiescent Myofibroblasts in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2009 Jul 13.


The expression patterns of GATA-6, the mesenchymal marker alpha-SMA and markers for proliferation (Ki67) and apoptosis (Caspase-3) were analyzed in human IPF/UIP tissue samples.
1(0,0,0,1) Details
20131370 Johnson BQ, Fox R, Chen X, Thibeault S: Tissue regeneration of the vocal fold using bone marrow mesenchymal stem cells and synthetic extracellular matrix injections in rats. Laryngoscope. 2010 Mar;120(3):537-45.


RESULTS: BM-MSC grown in vitro within sECM express Sca-1, are positive for hyaluronan receptor CD44, and continue to proliferate.
1(0,0,0,1) Details
20110838 Hunt KJ, Braun JT, Christensen BA: The effect of two clinically relevant fusionless scoliosis implant strategies on the health of the intervertebral disc: analysis in an immature goat model. Spine (Phila Pa 1976). 2010 Feb 15;35(4):371-7.


Qualitative and quantitative analyses were performed on spinal motion segments using H&E;, TUNEL, and caspase-3 staining.
1(0,0,0,1) Details
19288266 Grande MT, Arevalo M, Nunez A, Cannata-Andia JB, Santos E, Lopez-Novoa JM: Targeted genomic disruption of H-ras and N-ras has no effect on early renal changes after unilateral ureteral ligation. World J Urol. 2009 Mar 15.


Fibronectin, alpha-smooth muscle actin, cleaved caspase-3, ki-67, Ras-GTP, pERK, and pAkt expression was analyzed by western blot and/or immunohistochemistry.
1(0,0,0,1) Details
20219823 Kim J, Kim DS, Park M, Cho HJ, Zervos AS, Bonventre JV, Park KM: Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction. Am J Physiol Renal Physiol. 2010 Mar 10.


UUO reduced the X-linked inhibitor of apoptosis protein (XIAP), a substrate of Omi, and pro-caspase-3, whereas it increased cleaved poly ADP-ribose polymerase (cleaved PARP) and the number of terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells.
1(0,0,0,1) Details
19640900 Pang M, Kothapally J, Mao H, Tolbert E, Ponnusamy M, Chin YE, Zhuang S: Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol. 2009 Oct;297(4):F996-F1005. Epub 2009 Jul 29.


Finally, TSA treatment inhibited tubular cell apoptosis and caspase-3 activation in the obstructive kidney.
1(0,0,0,1) Details
18689869 Tabatabai G, Herrmann C, von Kurthy G, Mittelbronn M, Grau S, Frank B, Mohle R, Weller M, Wick W: VEGF-dependent induction of CD62E on endothelial cells mediates glioma tropism of adult haematopoietic progenitor cells. Brain. 2008 Oct;131(Pt 10):2579-95. Epub 2008 Aug 9.


Neutralizing antibodies to CD62E strongly reduced the homing of lin (-) Sca-1 (+) c-kit (+) cells to orthotopic SMA-560 gliomas in vivo.
1(0,0,0,1) Details