Protein Information

Name cytokeratin
Synonyms Cytokeratin; Cytokeratin type II; K6HF; KRT75; keratin 75; Cytokeratin type IIs; keratin 75s

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18400254 Qiu X, Montgomery E, Sun B: Inflammatory myofibroblastic tumor and low-grade myofibroblastic sarcoma: a comparative study of clinicopathologic features and further observations on the immunohistochemical profile of myofibroblasts. Hum Pathol. 2008 Jun;39(6):846-56. Epub 2008 Apr 8.


The primary antibodies used in this study were specific for the ultrastructural subcellular components: (1) *-smooth muscle actin (*-SMA), muscle-specific actin (MSA), calponin, and h-caldesmon for myofilaments; (2) fibronectin for fibronexus; (3) laminin for basal lamina; (4) desmin and cytokeratin for intermediate filaments.
2(0,0,0,2) Details
18941404 Westfall DE, Folpe AL, Paner GP, Oliva E, Goldstein L, Alsabeh R, Gown AM, Amin MB: Utility of a comprehensive immunohistochemical panel in the differential diagnosis of spindle cell lesions of the urinary bladder. Am J Surg Pathol. 2009 Jan;33(1):99-105.


Within the context of morphology, an immunohistochemical panel composed of broad-spectrum antibodies to cytokeratin as well as antibodies to SMA, ALK, p63, and CK 5/6 will be a useful diagnostic adjunct: a combination of pankeratin, SMA, and ALK positivity favors PMP; expression of several cytokeratin and especially CK 34betaE12 and CK 5/6 with p63 favors sarcomatoid carcinoma and SMA positivity with overall absence of other markers favors leiomyosarcoma.
1(0,0,0,1) Details
18227731 Vasei M, Moch H, Mousavi A, Kajbafzadeh AM, Sauter G: Immunohistochemical profiling of Wilms tumor: a tissue microarray study. Appl Immunohistochem Mol Morphol. 2008 Mar;16(2):128-34.


RESULTS: Blastemal elements expressed CD56 (22, 57%), CD57 (19, 55%), cytokeratin 22 (CK22) (12, 27%), and CK8 (9, 21%).
1(0,0,0,1) Details
17650214 Rizkalla H, Toner M: Necrotizing sialometaplasia versus invasive carcinoma of the head and neck: the use of myoepithelial markers and keratin subtypes as an adjunct to diagnosis. Histopathology. 2007 Aug;51(2):184-9.


AIMS: To investigate the use of immunohistochemistry in distinguishing necrotizing sialometaplasia (NSM) from squamous cell (SCC) and mucoepidermoid carcinoma (MEC) by (i) the identification of myoepithelial cells and (ii) cytokeratin (CK) expression.
1(0,0,0,1) Details
18460022 Sun B, Sun Y, Wang J, Zhao X, Zhang S, Liu Y, Li X, Feng Y, Zhou H, Hao X: The diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma: a review and prospective study of 255 cases. Cancer Sci. 2008 Jul;99(7):1355-61. Epub 2008 May 2.


The positive ratio of cytokeratin (CK) and epithelial membrane antigen (EMA) in finally diagnosed SS was 51.9% (55/106) and 61.3% (65/106), respectively.
1(0,0,0,1) Details
20150166 Pletinck A, Consoli C, Van Landschoot M, Steppan S, Topley N, Passlick-Deetjen J, Vanholder R, Van Biesen W: Salt intake induces epithelial-to-mesenchymal transition of the peritoneal membrane in rats. Nephrol Dial Transplant. 2010 Feb 11.


RESULTS: Dietary salt intake caused peritoneal fibrosis and thickening of the submesothelial layer and induced EMT as identified by colocalization of cytokeratin and alpha-SMA in cells present in the submesothelial layer.
1(0,0,0,1) Details
20032423 Angiero F, Sozzi D, Seramondi R, Valente MG: Epithelial-myoepithelial carcinoma of the minor salivary glands: immunohistochemical and morphological features. Anticancer Res. 2009 Nov;29(11):4703-9.


RESULTS: Immunohistochemical analysis showed the tumor cells to be weakly positive for S100, cytokeratin (CK) CK5/6, CK7, CKAE-1/AE-3 and strongly positive for epithelial membrane antigen (EMA) and p63; they were focally positive for calponin and acute lymphoblastic leukemia antigen (CD10).
1(0,0,0,1) Details
19234706 Sharma AK, Donovan JL, Hagerty JA, Sullivan RR, Edassery SL, Harrington DA, Cheng EY: Do current bladder smooth muscle cell isolation procedures result in a homogeneous cell population? Implications for bladder tissue engineering. World J Urol. 2009 Oct;27(5):687-94. Epub 2009 Feb 21.


Antibody staining of cultured cells consisted of alpha-SMA, von Willebrand factor, pan-cytokeratin, CD31, and CD90.
1(0,0,0,1) Details
19184024 Bocker W, Hungermann D, Decker T: [Anatomy of the breast] . Pathologe. 2009 Feb;30(1):6-12.


Immunofluorescence studies have shown that the breast epithelium contains cytokeratin (CK) 5/14-positive precursor cells which give rise to CK8/18-positive glandular or sm-actin-positive myoepithelial cells.
1(0,0,0,1) Details
19887789 Oh EJ, Ryu HM, Choi SY, Yook JM, Kim CD, Park SH, Chung HY, Kim IS, Yu MA, Kang DH, Kim YL: Impact of low glucose degradation product bicarbonate/lactate-buffered dialysis solution on the epithelial-mesenchymal transition of peritoneum. Am J Nephrol. 2010;31(1):58-67. Epub 2009 Nov 4.


Dual-stained cytokeratin and alpha-SMA-positive myofibroblasts in the submesothelial layer were more prominent in the H-GDP group.
1(0,0,0,1) Details
17943409 Yorulmaz G, Erdogan G, Pestereli HE, Savas B, Karaveli FS: Epithelioid leiomyosarcoma with rhabdoid features. Wien Klin Wochenschr. 2007;119(17-18):557-60.


Immunopositive cytoplasmic staining for myoglobulin and desmin was seen in rhabdoid cells, and cytokeratin immunopositivity was observed in epithelioid and some rhabdoid cells.
1(0,0,0,1) Details
18389991 Sirikulchayanonta V, Jaovisidh S: Including MIR of a primary bone leiomyosarcoma that radiologically mimics a giant cell tumor. J Med Assoc Thai. 2008 Feb;91(2):244-8.


The immuno-stains revealed positive reactivity for alpha-smooth muscle (SMA), muscle actin and cytokeratin (AE1/AE3).
1(0,0,0,1) Details
19035117 Li X, Liu HG, Xie XJ, Han YD, Li M: [Clinicopathologic study of sinonasal teratocarcinosarcoma and its contrast with olfactory neuroblastoma]. Zhonghua Bing Li Xue Za Zhi. 2008 Jul;37(7):458-64.


Cytokeratin (pan) was positive in epithelial cells.
1(0,0,0,1) Details
18564284 Missall TA, Burkemper NM, Jensen SL, Hurley MY: Immunohistochemical differentiation of four benign eccrine tumors. J Cutan Pathol. 2009 Feb;36(2):190-6. Epub 2008 Jun 17.


METHODS: Ten examples each of normal eccrine structures and of four benign eccrine tumors are analyzed with antibodies to cytokeratin (CK) 7, CD34, CK6, CK10, smooth muscle actin (SMA) and CD10.
1(0,0,0,1) Details
18261305 Luo DL, Liu YH, Zhuang HG, Luo XL: [Tumors showing perivascular epithelioid cell differentiation: a clinicopathologic study of 39 cases]. Zhonghua Yi Xue Za Zhi. 2007 Nov 6;87(41):2909-13.


Immunohistochemistry (HIC) was used to detect the expression of pan-cytokeratin (CK), S-100 protein, smooth muscle actin (SMA), desmin, vimentin, HMB45, Melan-A, microphthalmia transcription factor (MiTF), CD117, and CD34 in the specimens of the tumors obtained during operation.
1(0,0,0,1) Details
18197550 Nishioka Y, Miyazaki M, Abe K, Furusu A, Harada T, Ozono Y, Taguchi T, Koji T, Kohno S: Regeneration of peritoneal mesothelium in a rat model of peritoneal fibrosis. Ren Fail. 2008;30(1):97-105.


Expression of cytokeratin and HBME-1, markers for mesothelial cells, in these cells was delayed until day 7.
1(0,0,0,1) Details
18987833 Seno T, Kawaguchi T, Yamahara T, Sakurai Y, Oishi T, Inagaki T, Yamanouchi Y, Asai A, Kawamoto K: An immunohistochemical and electron microscopic study of atypical teratoid/rhabdoid tumor. Brain Tumor Pathol. 2008;25(2):79-83. Epub 2008 Nov 6.


However, immunohistochemical staining showed that these tumor cells react positively for cytokeratin, smooth muscle actin (SMA), and epithelial membrane antigen (EMA) and helped us with the differentiation.
1(0,0,0,1) Details
19526758 Chai JJ, Chen YP, Rui HL: [Effects of hirsutella sinensis on TGF-beta1 and snail expressions and transdifferentiation of tubular epithelial-myofibroblast in renal tissue of rats with chronic aristolochic acid nephropathy]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Apr;29(4):325-9.


All rats were sacrificed at the end of the 12th week, their kidney was taken for examining the degree of fibrosis in renal interstitial with Masson's stain and determining mRNA and protein expressions of transforming growth factor-beta1 (TGF-beta1), Snail, alpha-smooth muscle actin (alpha-SMA) and cytokeratin in renal tissue by Real-time RT-PCR and immunohistochemistry staining, respectively.
2(0,0,0,2) Details
17701211 Aresu L, Rastaldi MP, Scanziani E, Baily J, Radaelli E, Pregel P, Valenza F: Epithelial-mesenchymal transition (EMT) of renal tubular cells in canine glomerulonephritis. Virchows Arch. 2007 Nov;451(5):937-42. Epub 2007 Aug 15.


Immunohistochemistry showed the expression of the epithelial marker cytokeratin, the smooth muscle marker alpha-SMA, the mesenchymal marker vimentin and PCNA in 20 dogs with membranous glomerulonephritis and membrano-proliferative glomerulonephritis.
2(0,0,0,2) Details