| Name | calcium channel (protein family or complex) |
|---|---|
| Synonyms | calcium channel |
| Name | lindane |
|---|---|
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7694769 | Tusell JM, Barron S, Serratosa J: Anticonvulsant activity of delta-HCH, calcium channel blockers and calmodulin antagonists in seizures induced by lindane and other convulsant drugs. Brain Res. 1993 Sep 17;622(1-2):99-104. The anticonvulsant activity of delta-HCH and of a calmodulin antagonist, W-7 were investigated on convulsions induced in mice by lindane (ED100 100 mg/kg), by GABAergic antagonists PTZ (ED100 60 mg/kg) and PTX (ED100 4 mg/kg), by calcium channel agonist BAY-K-8644 (ED100 5 mg/kg), by two agonists of excitatory amino acid receptors, kainic acid (ED100 80 mg/kg) and (ED100 160 mg/kg and by the atypical benzodiazepine Ro 5-4864 (ED100 40 mg/kg). |
112(1,2,2,2) | Details |
| 11279263 | Katoh-Semba R, Takeuchi IK, Inaguma Y, Ichisaka S, Hata Y, Tsumoto T, Iwai M, Mikoshiba K, Kato K: Induction of brain-derived neurotrophic factor by convulsant drugs in the rat brain: involvement of region-specific voltage-dependent channels. J Neurochem. 2001 Apr;77(1):71-83. To elucidate possible mechanisms of endogenous BDNF increase, changes in levels of BDNF were studied in the rat brain following systemic administration of various convulsant agents; excitotoxic agonists, kainic acid and (+/-)-alpha-amino-3--5-methylisoxazole-4- (AMPA); GABA receptor antagonists, picrotoxin, pentylenetetrazole (PTZ) and lindane (gamma-hexachlorocyclohexane); and L-type voltage-dependent calcium channel agonist, BAY-K 8644. |
31(0,1,1,1) | Details |
| 7533233 | Planas AM, Soriano MA, Ferrer I, Rodriguez Farre E: Regional expression of inducible heat shock protein-70 mRNA in the rat brain following administration of convulsant drugs. Brain Res Mol Brain Res. 1994 Nov;27(1):127-37. Expression of inducible heat shock protein-70 mRNA (hsp-70 mRNA) was studied in the rat brain following systemic administration of different convulsant agents: an L-type voltage-dependent calcium channel agonist, (+/-)-BAY K 8644 (BAY-K); the excitotoxic agonists kainic acid and and the GABAA receptor complex antagonists pentylenetetrazole (PTZ) and lindane (gamma-hexaclorocyclohexane). |
31(0,1,1,1) | Details |
| 7531829 | Tusell JM, Barron S, Serratosa J: Anticonvulsant activity of calmodulin antagonist W-7 in convulsions induced by lindane and BayK-8644: effects in c-fos expression. Neurotoxicology. 1994 Fall;15(3):751-6. The anticonvulsant activity of calmodulin antagonist W-7, was investigated on convulsions induced in mice by the insecticide lindane and by the calcium channel agonist BayK-8644. |
31(0,1,1,1) | Details |
| 1280523 | Tusell JM, Vendrell M, Serratosa J, Trullas R: Lindane-induced convulsions in NMRI and OF1 mice: antagonism with (+) MK-801 and voltage-dependent calcium channel blockers. Brain Res. 1992 Oct 16;593(2):209-14. |
7(0,0,1,2) | Details |
| 20211194 | Gustafsson H, Runesson J, Lundqvist J, Lindegren H, Axelsson V, Forsby A: Neurofunctional endpoints assessed in human neuroblastoma SH-SY5Y cells for estimation of acute systemic toxicity. Toxicol Appl Pharmacol. 2010 Mar 6. We studied cell membrane potential (CMP), (NA) uptake, acetylcholine esterase (AChE) activity, acetylcholine receptor (AChR) signalling and voltage-operated calcium channel (VOCC) function in human neuroblastoma SH-SY5Y cells after exposure to 23 pharmaceuticals, pesticides or industrial chemicals. The CMP assay was the most sensitive assay, identifying eight chemicals as alerts and improving the LC50 correlation for lindane, atropine and methadone. |
1(0,0,0,1) | Details |
| 7680676 | Meera P, Tripathi O, Kamboj KK, Rao PR: Role of in biphasic immunomodulation by gamma-HCH (lindane) in mice. Immunopharmacol Immunotoxicol. 1993 Jan;15(1):113-29. Lymphocyte proliferation was inhibited during both the phases of immune response by a calcium channel blocker, and by trifluoperazine, a calmodulin inhibitor. |
1(0,0,0,1) | Details |