Protein Information

Name caldesmon
Synonyms CAD; Cad; CDM; CALD 1; CALD1; Caldesmon; Caldesmon 1; Caldesmon 1 isoform 1…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19015263 Jin L, Yoshida T, Ho R, Owens GK, Somlyo AV: The actin-associated protein Palladin is required for development of normal contractile properties of smooth muscle cells derived from embryoid bodies. J Biol Chem. 2009 Jan 23;284(4):2121-30. Epub 2008 Nov 17.


In the present study, smooth muscle cell (SMC) markers, such as myosin, actin, caldesmon, calponin, and LPP, were down-regulated in embryoid bodies (EBs) derived from embryonic stem cells lacking Palladin.
2(0,0,0,2) Details
20126587 Vasco PG, Rodriguez JL, Martinez JI, Campora RG, Davidson HG: Immunohistochemical organization patterns of the follicular dendritic cells, myofibroblasts and macrophages in the human spleen--new considerations on the pathological diagnosis of splenectomy pieces. Int J Clin Exp Pathol. 2009 Dec 10;3(2):189-202.


We analyzed the usefulness of the monoclonal antibodies CD45RO, CD20, CD21, CD35, CD68, caldesmon, the smooth muscle alpha-actin type 1 (SMA-1) in 91 specimens.
2(0,0,0,2) Details
19937078 Mouravas VK, Koletsa T, Sfougaris DK, Philippopoulos A, Petropoulos AS, Zavitsanakis A, Kostopoulos I: Smooth muscle cell differentiation in the processus vaginalis of children with hernia or hydrocele. Hernia. 2009 Nov 24.


The aim of this study was to evaluate the diversity and differentiation of smooth muscle phenotypes in sacs associated with inguinal hernia and hydrocele through the expression of alpha-smooth muscle actin (SMA), h-caldesmon, desmin, and vimentin.
2(0,0,0,2) Details
19281784 Orlandi A, Hao H, Ferlosio A, Clement S, Hirota S, Spagnoli LG, Gabbiani G, Chaponnier C: Alpha actin isoforms expression in human and rat adult cardiac conduction system. Differentiation. 2009 Apr;77(4):360-8. Epub 2009 Feb 4.


SAN and IB cardiomyocytes were characterized by the presence of alpha-SMA, alpha-CA, calponin and caldesmon, whereas alpha-SKA and vimentin were absent.
2(0,0,0,2) Details
19577381 Fraternali Orcioni G, Louis Ravetti J, Gaggero G, Bocca B, Bisceglia M: Primary embryonal spindle cell cardiac rhabdomyosarcoma: Case report. Pathol Res Pract. 2009 Jul 2.


Staining for alpha-SMA, H-caldesmon, CD34, epithelial membrane antigen (EMA), keratin wide-spectrum (CK w.s.), and S100 protein was negative.
1(0,0,0,1) Details
19391217 Marsh WL, Colonna J, Yearsley M, Bloomston M, Frankel WL: Calponin is expressed in serous cystadenomas of the pancreas but not in adenocarcinomas or endocrine tumors. Appl Immunohistochem Mol Morphol. 2009 May;17(3):216-9.


Subsequently, some were stained with MUC6, melan-A, D2-40, h-caldesmon, smooth muscle actin, and smooth muscle myosin.
1(0,0,0,1) Details
20169895 Sojka P, Pogrzebielski A, Orlowska-Heitzman J, Romanowska-Dixon B: [Mesectodermal leiomyoma of the ciliary body--case report] . Klin Oczna. 2009;111(10-12):350-3.


The co-expression of muscular (SMA, caldesmon, desmin), as well as neural markers (S-100 protein and synaptophysin), has been proved.
1(0,0,0,1) Details
18558191 Nakano R, Paran TS, Rolle U, Puri P: Age-related changes in the neuromuscular development of the internal anal sphincter. J Pediatr Surg. 2008 Jun;43(6):1106-10.


METHODS: Paraffin sections of IAS from 5 different age groups, E60, E90, 1 day, 4, and 12 weeks old, were stained with protein gene product 9.5 (PGP9.5), *-smooth muscle actin (*-SMA), caldesmon (CALD), calponin (CALP), and desmin (DES) antibodies.
1(0,0,0,1) Details
19407854 Zeine R, Salwen HR, Peddinti R, Tian Y, Guerrero L, Yang Q, Chlenski A, Cohn SL: Presence of cancer-associated fibroblasts inversely correlates with Schwannian stroma in neuroblastoma tumors. Mod Pathol. 2009 Jul;22(7):950-8. Epub 2009 May 1.


Cancer-associated fibroblasts were characterized by positive immunostaining for alpha-smooth muscle actin (alpha-SMA) and were distinguished from pericytes by staining negatively for high-molecular-weight caldesmon. alpha-SMA-positive cells were quantified and their number was defined as high when > 1.0% of the area was positive.
1(0,0,0,1) Details
17657261 Yan TQ, Yang RL, Guo W, Shen DH: [A case of primary leiomyosarcoma of tibia with multiple skeletal metastases]. Beijing Da Xue Xue Bao. 2007 Aug 18;39(4):369-73.


Immunohistochemistry revealed that the tumor cells were positive for smooth muscle antigen (SMA) and caldesmon.
1(0,0,0,1) Details
18400254 Qiu X, Montgomery E, Sun B: Inflammatory myofibroblastic tumor and low-grade myofibroblastic sarcoma: a comparative study of clinicopathologic features and further observations on the immunohistochemical profile of myofibroblasts. Hum Pathol. 2008 Jun;39(6):846-56. Epub 2008 Apr 8.


The primary antibodies used in this study were specific for the ultrastructural subcellular components: (1) *-smooth muscle actin (*-SMA), muscle-specific actin (MSA), calponin, and h-caldesmon for myofilaments; (2) fibronectin for fibronexus; (3) laminin for basal lamina; (4) desmin and cytokeratin for intermediate filaments.
1(0,0,0,1) Details
18571460 Kim YM, Jeon ES, Kim MR, Jho SK, Ryu SW, Kim JH: Angiotensin II-induced differentiation of adipose tissue-derived mesenchymal stem cells to smooth muscle-like cells. Int J Biochem Cell Biol. 2008;40(11):2482-91. Epub 2008 May 18.


In this study, we demonstrate that treatment of human adipose tissue-derived mesenchymal stem cells (hADSCs) with Ang II increased the expression of smooth muscle-specific genes, including alpha-smooth muscle actin (alpha-SMA), calponin, h-caldesmon, and smooth muscle myosin heavy chain (SM-MHC), and also elicited the secretion of transforming growth factor-beta1 (TGF-beta1) and delayed phosphorylation of Smad2.
1(0,0,0,1) Details