Protein Information

Name keratin 14
Synonyms CK 14; CK14; Cytokeratin 14; EBS 3; EBS 4; EBS3; EBS4; K14…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18847449 Kobayashi Y, Nakanishi Y, Taniguchi H, Sekine S, Igaki H, Tachimori Y, Kato H, Matsubara H, Okazumi S, Shimoda T: Histological diversity in basaloid squamous cell carcinoma of the esophagus. Dis Esophagus. 2009;22(3):231-8. Epub 2008 Oct 10.


Immunoreactivity for CK7, CK14, and SMA was seen in 10.5, 86.8, and 18.4% of SN; 30.8, 97.4, and 38.5% of MT; 54.5, 100.0, and 54.5% of DD; 7.7, 76.9, and 23.1% of CP; and 6.1, 97.0, and 0.0% of SCC, respectively.
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19184024 Bocker W, Hungermann D, Decker T: [Anatomy of the breast] . Pathologe. 2009 Feb;30(1):6-12.


Diagnostically important cytokeratins of normal breast epithelium and its proliferative epithelial processes include luminal cytokeratins (CK7, CK8 and CK18) as markers of glandular differentiation and basal cytokeratins (CK5, CK14 and CK17) as markers of progenitor cells and early cells of the glandular and myoepithelial differentiation pathway.
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19862337 Barbaro V, Ferrari S, Fasolo A, Ponzin D, Di Iorio E: Reconstruction of a human hemicornea through natural scaffolds compatible with the growth of corneal epithelial stem cells and stromal keratocytes. Mol Vis. 2009 Oct 17;15:2084-93.


The basal cuboidal epithelial cells were anchored to the basement membrane and expressed keratin 14 and alpha6, beta1, and beta4 integrins.
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18227731 Vasei M, Moch H, Mousavi A, Kajbafzadeh AM, Sauter G: Immunohistochemical profiling of Wilms tumor: a tissue microarray study. Appl Immunohistochem Mol Morphol. 2008 Mar;16(2):128-34.


Only one case was positive for CK5/6, CK13, CK14, and CK20.
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19843143 Delgallo WD, Rodrigues JR, Bueno SP, Viero RM, Soares CT: Cell blocks allow reliable evaluation of expression of basal (CK5/6) and luminal (CK8/18) cytokeratins and smooth muscle actin (SMA) in breast carcinoma. Cytopathology. 2009 Oct 15.


Luminal carcinomas express cytokeratins in a luminal pattern (CK8/18), and the basal-like type expresses CK5/6 and CK14 or basal epithelial cell markers.
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20223349 Defaud-Henon F, Tunon-de-Lara C, Fournier M, Marty M, Velasco V, de Mascarel I, MacGrogan G: [Adenoid cystic carcinoma of the breast: clinical, histological and immunohistochemical characterization]. Ann Pathol. 2010 Feb;30(1):7-16. Epub 2010 Feb 18.


An immunohistochemical study was performed with the following antibodies: ER, PR, HER-2-neu, Vimentin, EGFR, P63, SMA, CK5/6, CK8/18, CK14, cKIT, MIB1, CD44 and CD24.
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18807040 Mainka P, Kahlert S, Kirchner T, Mayr D, Diebold J: [Basal and myoepithelial phenotype of metastatic mammary carcinomas. Pathologe. 2008 Nov;29 Suppl 2:363-9.


METHODS: Paraffin-embedded material from 244 primary breast carcinomas of patients with subsequent metastatic disease was stained immunohistochemically for CK 5/6, CK14, smooth-muscle actin, p63, estrogen receptor and progesterone receptor.
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19855377 Thike AA, Cheok PY, Jara-Lazaro AR, Tan B, Tan P, Tan PH: Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer. Mod Pathol. 2010 Jan;23(1):123-33. Epub 2009 Oct 23.


Using a set of 61 invasive breast cancers earlier profiled into molecular subtypes with expression arrays, we defined specificity and sensitivity values for different immunohistochemical panels of basal keratins (CK5/6, CK14, CK17, 34 beta E12), CD117, EGFR, p63 and SMA in defining basal-like breast cancer.
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