Protein Information

Name myosin light chain kinase
Synonyms MLCK; Myosin light chain kinase; MLCK 2; MLCK2; MLCK protein; MLCK proteins

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
17720771 Allahdadi KJ, Walker BR, Kanagy NL: ROK contribution to endothelin-mediated contraction in aorta and mesenteric arteries following intermittent hypoxia/hypercapnia in rats. Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2911-8. Epub 2007 Aug 24.

In contrast, inhibition of myosin light-chain kinase (ML-9, 100 microM) prevented ET-1-mediated constriction in sMA from both groups.
81(1,1,1,1) Details
19577256 Yang G, Xu J, Li T, Ming J, Chen W, Liu L: Role of V (1a) Receptor in AVP-Induced Restoration of Vascular Hyporeactivity and Its Relationship to MLCP-MLC (20) Phosphorylation Pathway. J Surg Res. 2009 Jan 27.


Meanwhile the effects of AVP and V (1a) and V (2) receptor antagonists on the activity of MLCP and myosin light chain kinase (MLCK), and the phosphorylation of MLC (20), and the expression of PKC-alpha, delta, and epsilon isoforms were also studied.
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18845763 Kim MR, Jeon ES, Kim YM, Lee JS, Kim JH: Thromboxane a (2) induces differentiation of human mesenchymal stem cells to smooth muscle-like cells. Stem Cells. 2009 Jan;27(1):191-9.


These results suggest that U46619 induces differentiation of hADSCs to contractile smooth muscle-like cells through CaM/MLCK- and RhoA-Rho kinase-dependent actin polymerization.
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17666953 Li T, Liu L, Liu J, Ming J, Xu J, Yang G, Zhang Y: Mechanisms of Rho kinase regulation of vascular reactivity following hemorrhagic shock in rats. Shock. 2008 Jan;29(1):65-70.


With isolated superior mesenteric artery (SMA) from hemorrhagic shock rats, we studied the relationship of Rho kinase regulating vascular reactivity to calcium sensitivity and myosin light chain phosphatase (MLCP) and myosin light chain kinase (MLCK).
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18766098 Christie JD, Ma SF, Aplenc R, Li M, Lanken PN, Shah CV, Fuchs B, Albelda SM, Flores C, Garcia JG: Variation in the MYLK gene is associated with development of acute lung injury after major trauma. Crit Care Med. 2008 Aug 28.


BACKGROUND:: Single nucleotide polymorphisms in the myosin light chain kinase gene (MYLK) have been implicated in the risk of sepsis-related acute lung injury and asthma.
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