Protein Information

Name elastin
Synonyms ELN; WS; WBS; Elastin; Elastin precursor; SVAS; Tropoelastin; Elastins…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19283727 Kurane A, Vyavahare N: In vivo vascular tissue engineering: influence of cytokine and implant location on tissue specific cellular recruitment. J Tissue Eng Regen Med. 2009 Jun;3(4):280-9.


Elastin is necessary to sustain continual pulsatile flow and to prevent the dilatation of vascular tissues.
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19636108 Zhang L, Spector M: Comparison of three types of chondrocytes in collagen scaffolds for cartilage tissue engineering. Biomed Mater. 2009 Jul 28;4(4):45012.


After four weeks of culture, the constructs were prepared for histochemical and immunohistochemical analysis of the distribution of glycosaminoglycan (GAG), types I and II collagen, elastin, SM and lubricin.
1(0,0,0,1) Details
18824769 Iwasaki K, Kojima K, Kodama S, Paz AC, Chambers M, Umezu M, Vacanti CA: Bioengineered three-layered robust and elastic artery using hemodynamically-equivalent pulsatile bioreactor. Circulation. 2008 Sep 30;118(14 Suppl):S52-7.


Elastica Van Gieson and Masson Tricrome Stain revealed ample production of elastin and collagen in the engineered grafts.
1(0,0,0,1) Details
20213136 Langlois D, Hneino M, Bouazza L, Parlakian A, Sasaki T, Bricca G, Li JY: Conditional inactivation of TGF-beta type II receptor in smooth muscle cells and epicardium causes lethal aortic and cardiac defects. Transgenic Res. 2010 Mar 6.


Tgfbr2 deletion in the VSMCs of the descending thoracic aorta diminished the number of alpha-SMA-positive VSMC progenitors in the media at E11.5 and drastically decreased tropoelastin (from E11.5) and fibulin-5 (from E.12.5) synthesis and/or deposition.
1(0,0,0,1) Details
17846326 Sales VL, Engelmayr GC Jr, Johnson JA Jr, Gao J, Wang Y, Sacks MS, Mayer JE Jr: Protein precoating of elastomeric tissue-engineering scaffolds increased cellularity, enhanced extracellular matrix protein production, and differentially regulated the phenotypes of circulating endothelial progenitor cells. Circulation. 2007 Sep 11;116(11 Suppl):I55-63.


METHODS AND RESULTS: Elastomeric poly (glycerol sebacate) scaffolds were precoated with laminin, fibronectin, fibrin, collagen types I/III, or elastin.
1(0,0,0,1) Details
17868878 Mendelson K, Aikawa E, Mettler BA, Sales V, Martin D, Mayer JE, Schoen FJ: Healing and remodeling of bioengineered pulmonary artery patches implanted in sheep. Cardiovasc Pathol. 2007 Sep-Oct;16(5):277-82. Epub 2007 Jun 21.


After 4 weeks in vivo, seeded patches contained glycosaminoglycans, collagen, and coverage of the luminal surface by host artery-derived pannus containing alpha-SMA-positive cells and laminated elastin; polymer scaffold degradation was almost complete with replacement by fibrous tissue containing viable cells.
1(0,0,0,1) Details