| Name | heme oxygenase 1 |
|---|---|
| Synonyms | HMOX 1; HMOX1; HMOX1 protein; HO; HO 1; HO1; Heme oxygenase (Decycling) 1; Heme oxygenase (Decyclizing) 1… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18024796 | Mayerhofer M, Gleixner KV, Mayerhofer J, Hoermann G, Jaeger E, Aichberger KJ, Ott RG, Greish K, Nakamura H, Derdak S, Samorapoompichit P, Pickl WF, Sexl V, Esterbauer H, Schwarzinger I, Sillaber C, Maeda H, Valent P: Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib. Blood. 2008 Feb 15;111(4):2200-10. Epub 2007 Nov 16. |
6(0,0,0,6) | Details |
| 20096777 | Shin DH, Park HM, Jung KA, Choi HG, Kim JA, Kim DD, Kim SG, Kang KW, Ku SK, Kensler TW, Kwak MK: The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis. Free Radic Biol Med. 2010 Apr 15;48(8):1051-63. Epub 2010 Jan 22. |
5(0,0,0,5) | Details |
| 17671894 | Fang J, Nakamura H, Iyer AK: Tumor-targeted induction of oxystress for cancer therapy. J Drug Target. 2007 Aug-Sep;15(7-8):475-86. More recently, a pegylated (PEG) zinc (PEG-ZnPP) and a highly water soluble micellar formulation of ZnPP based on amphiphilic styrene (SMA) copolymer, SMA-ZnPP, are prepared, which are potent inhibitors of heme oxygenase-1 (HO-1). |
4(0,0,0,4) | Details |
| 19249331 | Fang J, Seki T, Maeda H: Therapeutic strategies by modulating stress in cancer and inflammation. Adv Drug Deliv Rev. 2009 Apr 28;61(4):290-302. Epub 2009 Feb 26. Such therapeutic strategies are described in this article, that includes polymeric superoxide dismutase (SOD) (e.g., pyran copolymer-SOD), xanthine oxidase (XO) inhibitor as we developed water soluble form of 4-amino-6-hydroxypyrazolo [3,4-d] pyrimidine (AHPP), heme oxygenase-1 (HO-1) inducers (e.g., hemin and its polymeric form), and other antioxidants or radical scavengers (e.g., canolol). |
3(0,0,0,3) | Details |
| 17671896 | Iyer AK, Greish K, Seki T, Okazaki S, Fang J, Takeshita K, Maeda H: Polymeric micelles of zinc for tumor targeted delivery based on EPR effect and singlet generation. J Drug Target. 2007 Aug-Sep;15(7-8):496-506. The micellar macromolecular drug of ZnPP (SMA-ZnPP and PEG-ZnPP) previously showed notable anticancer activity as a consequence of selective tumor targeting ability and its potent HO-1 inhibitory potential, resulting in suppressed / production in tumors thereby leading to oxystress induced tumor cell killing. |
2(0,0,0,2) | Details |
| 18479415 | Ogasawara T, Morine Y, Ikemoto T, Imura S, Shimada M: Beneficial effects of Kampo medicine Inchin-ko-to on liver function and regeneration after hepatectomy in rats. Hepatol Res. 2008 Aug;38(8):818-24. Epub 2008 May 12. Liver sections were stained using immunohistochemistry (hemeoxygenase-1 [HO-1], alpha-smooth muscle actin [SMA], and proliferating cell nuclear antigen [PCNA]). |
2(0,0,0,2) | Details |
| 18328066 | Maeda K, Koda M, Matono T, Sugihara T, Yamamoto S, Ueki M, Murawaki Y, Yamashita N, Nishiyama S: Preventive effects of ME3738 on hepatic fibrosis induced by bile duct ligation in rats. Hepatol Res. 2008 Jul;38(7):727-35. Epub 2008 Mar 4. The gene expressions of collagen-I, transforming growth factor-beta1 (TGF-beta1), tissue inhibitor of metalloproteinases-1 (TIMP-1), interleukin-6 (IL-6) and heme oxygenase-1 (HO-1) in the liver were examined by real-time reverse transcriptase polymerase chain reaction (RT-PCR). |
2(0,0,0,2) | Details |
| 18723263 | Hadzijusufovic E, Rebuzzi L, Gleixner KV, Ferenc V, Peter B, Kondo R, Gruze A, Kneidinger M, Krauth MT, Mayerhofer M, Samorapoompichit P, Greish K, Iyer AK, Pickl WF, Maeda H, Willmann M, Valent P: Targeting of heat-shock protein 32/heme oxygenase-1 in canine mastocytoma cells is associated with reduced growth and induction of apoptosis. Exp Hematol. 2008 Nov;36(11):1461-70. Epub 2008 Aug 23. |
2(0,0,0,2) | Details |
| 19508170 | Gleixner KV, Mayerhofer M, Vales A, Gruze A, Hormann G, Cerny-Reiterer S, Lackner E, Hadzijusufovic E, Herrmann H, Iyer AK, Krauth MT, Pickl WF, Marian B, Panzer-Grumayer R, Sillaber C, Maeda H, Zielinski C, Valent P: Targeting of Hsp32 in solid tumors and leukemias: a novel approach to optimize anticancer therapy. Curr Cancer Drug Targets. 2009 Aug;9(5):675-89. Epub 2009 Aug 1. Heat shock protein 32 (Hsp32), also known as heme oxygenase-1 (HO-1), is a stress-related anti-apoptotic molecule, that has been implicated in enhanced survival of neoplastic cells and in drug-resistance. |
1(0,0,0,1) | Details |
| 19822164 | Tsai MK, Lin YL, Huang YT: Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats. Toxicol Appl Pharmacol. 2010 Jan 15;242(2):155-64. Epub 2009 Oct 12. In vivo studies showed that the hepatic levels of collagen, malondialdehyde, TNF-alpha, IL-6, and IL-1beta, fibrosis scores and protein expressions of alpha-SMA, heme-oxygenase-1, iNOS, and gp91 (phox), and serum levels of ALT, AST, IL-6, and IL-1beta were increased in TAA-intoxicated rats, all of which were attenuated by 4-week treatment of Sal A or Sal B. |
1(0,0,0,1) | Details |
| 18662738 | Wojcikowski K, Wohlmuth H, Johnson DW, Gobe G: Dioscorea villosa (wild yam) induces chronic kidney injury via pro-fibrotic pathways. Food Chem Toxicol. 2008 Sep;46(9):3122-31. Epub 2008 Jul 10. Protein expression levels of the pro-inflammatory cytokine, TNF-alpha, the pro-fibrotic transcription factor, NFkappaB, a measure of oxidative stress (heme oxygenase-1), alpha-SMA, vimentin and TGFss1 were determined. |
1(0,0,0,1) | Details |