Protein Information

Name cyclooxygenase 2
Synonyms COX 2; COX2; PHS2; PGG/HS; Cyclooxygenase 2; Cyclooxygenase 2b; Cycloxygenase 2; PGH synthase 2…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
20064200 Mattyasovszky SG, Hofmann A, Brochhausen C, Ritz U, Kuhn S, Wollstadter J, Schulze-Koops H, Muller LP, Watzer B, Rommens PM: The effect of the pro-inflammatory cytokine tumor necrosis factor-alpha on human joint capsule myofibroblasts. Arthritis Res Ther. 2010 Jan 8;12(1):R4.


MFs were challenged with different concentrations of TNF-alpha with or without both its specifically inactivating antibody infliximab (IFX) and cyclooxygenase-2 (COX2) inhibitor diclofenac.
3(0,0,0,3) Details
18462380 Kim SM, Park KC, Kim HG, Han SJ: Effect of selective cyclooxygenase-2 inhibitor meloxicam on liver fibrosis in rats with ligated common bile ducts. Hepatol Res. 2008 Aug;38(8):800-9. Epub 2008 May 7.

2(0,0,0,2) Details
19554635 Kourelis K, Vandoros G, Kourelis T, Papadas T, Goumas P, Sotiropoulou-Bonikou G: Low COX2 in tumor and upregulation in stroma mark laryngeal squamous cell carcinoma progression. Laryngoscope. 2009 Sep;119(9):1723-9.

2(0,0,0,2) Details
19335429 Chen YF, Chao CM, Liu HN: Cutaneous plasma cell granuloma: report of a case with novel histologic and immunohistochemical findings. Int J Dermatol. 2009 Apr;48(4):409-11.


Abundant CD68+ macrophages were observed within the lesion (Fig. 3a), and about 50-75% of the inflammatory cells were found to express cyclooxygenase-2 (COX-2) (Fig. 3b).
1(0,0,0,1) Details
20133451 Schell C, Albrecht M, Spillner S, Mayer C, Kunz L, Kohn FM, Schwarzer U, Mayerhofer A: 15-Deoxy-delta 12-14-prostaglandin-J2 induces hypertrophy and loss of contractility in human testicular peritubular cells: implications for human male fertility. Endocrinology. 2010 Mar;151(3):1257-68. Epub 2010 Feb 4.


In these cases, testicular expression of cyclooxygenase-2 (COX-2) implies formation of prostaglandins (PGs).
1(0,0,0,1) Details
19034132 Kawamura A, Tatsuguchi A, Ishizaki M, Takahashi H, Fukuda Y: Expression of microsomal prostaglandin e synthase-1 in fibroblasts of rabbit alkali-burned corneas. Cornea. 2008 Dec;27(10):1156-63.


Using immunostaining, the localization of mPGES-1, cyclooxygenase (COX)-2, and alpha-smooth muscle actin (alpha-SMA) protein was studied.
1(0,0,0,1) Details