Protein Information

Name progesterone receptor
Synonyms NR3C3; PGR; PR; Progesterone receptor; Progesterone receptors

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18032694 Kane N, Jones M, Brosens JJ, Saunders PT, Kelly RW, Critchley HO: Transforming growth factor-beta1 attenuates expression of both the progesterone receptor and Dickkopf in differentiated human endometrial stromal cells. Mol Endocrinol. 2008 Mar;22(3):716-28. Epub 2007 Nov 21.

Moreover, although TGFbeta1 was capable of signaling via the Sma- and mothers against decapentaplegic (MAD)-related protein (SMAD) pathway, the inhibitory effect on DKK was SMAD independent.
2(0,0,0,2) Details
18807143 Matsumoto M, Hayashi Y, Ohtsuki Y, Ikegami N, Toi M, Iguchi M, Hiroi M: Signet-ring stromal tumor of the ovary: an immunohistochemical and ultrastructural study with a review of the literature. Med Mol Morphol. 2008 Sep;41(3):165-70. Epub 2008 Sep 20.


Immunohistochemically, the tumor cells variously expressed several markers, including CD56, inhibin-alpha, alpha-smooth muscle actin (alpha-SMA), and progesterone receptor (PR), which have been identified in ovarian sex cord-stromal neoplasms.
1(0,0,0,1) Details
18807040 Mainka P, Kahlert S, Kirchner T, Mayr D, Diebold J: [Basal and myoepithelial phenotype of metastatic mammary carcinomas. Pathologe. 2008 Nov;29 Suppl 2:363-9.


METHODS: Paraffin-embedded material from 244 primary breast carcinomas of patients with subsequent metastatic disease was stained immunohistochemically for CK 5/6, CK14, smooth-muscle actin, p63, estrogen receptor and progesterone receptor.
1(0,0,0,1) Details
19093260 Hornychova H, Melichar B, Tomsova M, Mergancova J, Urminska H, Ryska A: Tumor-infiltrating lymphocytes predict response to neoadjuvant chemotherapy in patients with breast carcinoma. Cancer Invest. 2008 Dec;26(10):1024-31.

Ten patients with pathological complete response had significantly higher p53 expression, CD3 (+) lymphocyte and CD83 (+) cell counts, and lower progesterone receptor expression.
In the remaining 63 patients, a significant decrease in the percentage of Ki-67, vascular endothelial growth factor expression, CD68 (+) monocytes, and increased CD31 (+), CD34 (+), and SMA (+) stromal vessels, maximal CD3 (+) and CD56 (+) lymphocyte, maximal and mean CD83 (+) cell, maximal CD1a (+), and maximal and mean S100 (+) cell counts were observed after neoadjuvant chemotherapy.
1(0,0,0,1) Details