Protein Information

Name ED1
Synonyms ED1; ED1 A1; ED1 A2; EDA; EDA protein; EDA 1; EDA 2; EDA1…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18759748 Srisawat N, Manotham K, Eiam-Ong S, Katavetin P, Praditpornsilpa K, Eiam-Ong S: Erythropoietin and its non-erythropoietic derivative: do they ameliorate renal tubulointerstitial injury in ureteral obstruction?. Int J Urol. 2008 Oct;15(11):1011-7. Epub 2008 Aug 26.


After days 3, 7, and 14 of UUO, TI injury, collagen, alpha-smooth muscle actin (alpha-SMA) positive cell, ED1-positive cell, terminal deoxynucleotidyl transferase (TdT) mediated nick-end labeling (TUNEL)-positive cell, and transforming growth factor-beta1 (TGF-beta1) messenger ribonucleic acid (mRNA) were determined.
3(0,0,0,3) Details
19730414 Lu H, Kanazawa M, Ishida A, Tufescu A, Sasaki Y, Ito O, Kurosawa H, Sato T, Ootaka T, Kohzuki M: Combination of chronic exercise and antihypertensive therapy enhances renoprotective effects in rats with renal ablation. Am J Hypertens. 2009 Oct;22(10):1101-6. Epub 2009 Sep 3.


RESULTS: EX, EX+OLS, EX+AZN, and EX+OLS+AZN showed decreases in the serum creatinine (Scr), an index of glomerular sclerosis (IGS), the relative interstitial volume of the renal cortex (RIV), the number of ED-1 (monoclonal antibody) positive cells (ED1 (+)) and the glomerular expression score of alpha-smooth muscle actin (alpha-SMA (+)).
2(0,0,0,2) Details
19461215 Do SH, Hong IH, Park JK, Ji AR, Kim TH, Kwak DM, Jeong KS: Two different types of malignant fibrous histiocytomas from pet dogs. J Vet Sci. 2009 Jun;10(2):169-71.


To classify these tumors, we applied a panel of antibodies (vimentin, desmin, alpha-SMA, and ED1) and Azan staining for collagen.
2(0,0,0,2) Details
18087173 El Kossi MM, Haylor JL, Johnson TS, El Nahas AM: Stem cell factor in a rat model of serum nephrotoxic nephritis. . Nephron Exp Nephrol. 2008;108(1):e1-e10. Epub 2007 Dec 17.


Rats' kidneys were immunostained for ED1 as marker of inflammation, CD34, SCF, c-kit, mast cell tryptase and markers of fibrosis; collagens III and IV and alpha-SMA.
2(0,0,0,2) Details
19910699 Barreira AL, Takiya CM, Castiglione RC, Maron-Gutierrez T, Barbosa CM, Ornellas DS, Verdoorn KS, Pascarelli BM, Borojevic R, Einicker-Lamas M, Leite M Jr, Morales MM, Vieyra A: Bone marrow mononuclear cells attenuate interstitial fibrosis and stimulate the repair of tubular epithelial cells after unilateral ureteral obstruction. Cell Physiol Biochem. 2009;24(5-6):585-94. Epub 2009 Nov 4.


UUO+BMMC also showed a reduction in ED1 (+) cells and tubular apoptotic cells together with enhanced tubular proliferation.
1(0,0,0,1) Details
19390220 Takahashi S, Taniguchi Y, Nakashima A, Arakawa T, Kawai T, Doi S, Ito T, Masaki T, Kohno N, Yorioka N: Mizoribine suppresses the progression of experimental peritoneal fibrosis in a rat model. Nephron Exp Nephrol. 2009;112(2):e59-69. Epub 2009 Apr 23.


Macrophage infiltration (ED1), myofibroblast accumulation (alpha-smooth muscle actin (SMA)) and expression of type III collagen, transforming growth factor (TGF)-beta and monocyte chemotactic protein-1 (MCP-1) were examined by immunohistochemistry.
1(0,0,0,1) Details
20159698 He Y, Chen BL, Yang RP, Ren M, Zeng ZR: [Comparison of the pathogenesis of liver fibrosis induced by pig serum exposure and bile duct ligation in rats.]. Nan Fang Yi Ke Da Xue Xue Bao. 2010 Feb;30(2):270-4.


The Knodell score was used to evaluate the histological changes in the liver, and immunohistochemistry was performed using anti-SMA, anti-ED1, anti-CK7, and anti-CD45 antibodies.
1(0,0,0,1) Details
19589538 Liu M, Gu M, Wu Y, Zhu P, Zhang W, Yin C, Zhang WJ: Therapeutic effect of Y-27632 on chronic allograft nephropathy in rats. J Surg Res. 2009 Nov;157(1):e117-27. Epub 2008 Nov 24.


Attenuation of ED1 positive mononuclear cell infiltration and amelioration of tubulointerstitial fibrosis were achieved by Y-27632 intervention.
1(0,0,0,1) Details