Protein Information

Name interferon (protein family or complex)
Synonyms Interferon

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19001734 Yang HX, Yi YR: [Curative effect of interferon-alpha on rat liver fibrosis induced by CCl4]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Oct;33(10):919-25.

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18509673 Egritas O, Sari S, Dalgic B, Vural C, Akyol G: Granulomatous hepatitis, perihepatic lymphadenopathies, and autoantibody positivity: an unusual association in a child with hepatitis C. Eur J Pediatr. 2009 Mar;168(3):275-9. Epub 2008 May 29.


After interferon (IFN) and ribavirin therapy, HCV RNA became negative, along with the resolution of hepatic granulomas (HG), lymphadenopathies, and SMA positivity.
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18353212 Rao HY, Li J, Zhang LF, Chen HY, Zhu LM, Wei L, Sun Y, Wang H: [Effect of pegylated interferon beta-1a therapy on the liver fibrosis in chronic hepatitis C: a semi-quantitative analysis]. Zhonghua Yi Xue Za Zhi. 2008 Jan 8;88(2):96-100.


OBJECTIVE: To access the effect of pegylated interferon (PEGIFN) beta-1a on the reduction of liver fibrosis in chronic hepatitis C (HVC).
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17572012 Santak G, Santak M, Forcic D: Native human IFN-alpha is a more potent suppressor of HDF response to profibrotic stimuli than recombinant human IFN-alpha. J Interferon Cytokine Res. 2007 Jun;27(6):481-90.


Interferon-alpha (IFN-alpha) inhibits fibroblast proliferation, differentiation into myofibroblasts, and extracellular matrix synthesis, which are key events during both normal wound repair and fibrotic lesion formation.
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18052725 Wang J, Jiao H, Stewart TL, Shankowsky HA, Scott PG, Tredget EE: Improvement in postburn hypertrophic scar after treatment with IFN-alpha2b is associated with decreased fibrocytes. J Interferon Cytokine Res. 2007 Nov;27(11):921-30.


Previous clinical studies from our laboratory have suggested that interferon-alpha2b (IFN-alpha2b) improves scar quality as a result of suppression of fibroblast functions.
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