Protein Information

Name TIMP 2
Synonyms CSC 21K; Metalloproteinase inhibitor 2; Metalloproteinase inhibitor 2 precursor; TIMP metallopeptidase inhibitor 2; TIMP 2; TIMP2; Tissue inhibitor of metalloproteinase 2; Tissue inhibitor of metalloproteinases 2…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19543302 Yan JD, Yang S, Zhang J, Zhu TH: BMP6 reverses TGF-beta1-induced changes in HK-2 cells: implications for the treatment of renal fibrosis. Acta Pharmacol Sin. 2009 Jul;30(7):994-1000. Epub 2009 Jun 22.


The expression of fibronectin, collagen IV, matrix metalloproteinases 2 (MMP-2), and tissue inhibitors of matrix metalloproteinases 2 (TIMP-2) were analyzed using RT-PCR.
2(0,0,0,2) Details
19391484 Wagrowska-Danilewicz M, Danilewicz M: Aberrant tubulointerstitial immunoexpression of matrix metalloproteinases MMP-2, MMP-9 and tissue inhibitor of matrix proteinase-2 (TIMP-2) in acute cellular rejection of human renal allograft. Pol J Pathol. 2008;59(4):189-94.

2(0,0,0,2) Details
19376089 Szuster-Ciesielska A, Plewka K, Daniluk J, Kandefer-Szerszen M: Zinc supplementation attenuates ethanol- and acetaldehyde-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS) production and by influencing intracellular signaling. Biochem Pharmacol. 2009 Aug 1;78(3):301-14. Epub 2009 Apr 17.


Zinc down-regulated ethanol- and acetaldehyde-induced production of TIMP-1 and TIMP-2 and decreased the activity of MMP-2.
1(0,0,0,1) Details
20034937 Schweitzer M, Mitmaker B, Obrand D, Sheiner N, Abraham C, Dostanic S, Meilleur M, Sugahara T, Chalifour LE: Atorvastatin modulates matrix metalloproteinase expression, activity, and signaling in abdominal aortic aneurysms. Vasc Endovascular Surg. 2010 Feb;44(2):116-22. Epub 2009 Dec 23.


Matrix metalloproteinase 1, MMP2, MMP3, MMP9, Tissue Inhibitor of Metalloproteinase (TIMP2), TIMP3, TIMP4, or total Sma Mothers Against Decapentaplegia (SMAD2) expression did not differ with treatment.
0(0,0,0,0) Details
19517234 Nie QH, Zhu CL, Zhang YF, Yang J, Zhang JC, Gao RT: Inhibitory Effect of Antisense Oligonucleotide Targeting TIMP-2 on Immune-Induced Liver Fibrosis. Dig Dis Sci. 2009 Jun 11.

7(0,0,0,7) Details
18996463 Mu Y, Liu P, Du G, Du J, Wang G, Long A, Wang L, Li F: Action mechanism of Yi Guan Jian Decoction on CCl4 induced cirrhosis in rats. J Ethnopharmacol. 2009 Jan 12;121(1):35-42. Epub 2008 Oct 18.


At 12th weekend, the rats were sacrificed for sampling and detection of liver function, histological changes of liver tissue, liver tissue hydroxyproline content and expression of alpha-SMA, CD68, MMP-13, TIMP-1, TIMP-2, Caspase-12, HGFalpha, MMP-2, MMP-9 and hepatocyte apoptotic index.
3(0,0,0,3) Details