| Name | TIMP 1 |
|---|---|
| Synonyms | CLGI; Collagenase inhibitor; EPA; EPO; Erythroid potentiating activity; Fibroblast collagenase inhibitor; HCI; Metalloproteinase inhibitor 1… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18251166 | Zhang LJ, Zheng WD, Chen YX, Huang YH, Chen ZX, Zhang SJ, Shi MN, Wang XZ: Antifibrotic effects of interleukin-10 on experimental hepatic fibrosis. . Hepatogastroenterology. 2007 Oct-Nov;54(79):2092-8. The expression of TGF-beta1, MMP-2 and TIMP-1 in the liver tissues was measured by S-P immunohistochemistry. |
6(0,0,0,6) | Details |
| 18390195 | Xue H, Chen L, Fan JM, Li Z: [Role of MMP-9 and TIMP-1 in renal tubular epithelial-myofibroblast transdifferentiation]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Jan;39(1):34-8. |
6(0,0,0,6) | Details |
| 17708605 | Qiu JF, Zhang ZQ, Chen W, Wu ZY: Cystamine ameliorates liver fibrosis induced by carbon tetrachloride via inhibition of tissue transglutaminase. World J Gastroenterol. 2007 Aug 28;13(32):4328-32. Real-time PCR was used to detect the expression of tTG, smooth muscle alpha actin (alpha-SMA), tissue inhibitor of metalloproteinase 1 (TIMP-1) and collagen-1 mRNA. |
3(0,0,0,3) | Details |
| 18703961 | Finkel RS, Hynan LS, Glanzman AM, Owens H, Nelson L, Cone SR, Campbell SK, Iannaccone ST: The test of infant motor performance: reliability in spinal muscular atrophy type I. Pediatr Phys Ther. 2008 Fall;20(3):242-6. PURPOSE: The aim of this article was to determine reliability of the Test of Infant Motor Performance (TIMP) in infants with spinal muscular atrophy, type I (SMA-I). |
3(0,0,0,3) | Details |
| 18390206 | Tao Y, Wu X, Li DD, Liu QF, Bo H, Wang XR: [Experimental study in renal protective effect of tranilast on rats with adriamycin nephropathy]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Jan;39(1):76-9. And immunohistochemistry was used to examine the expression of transforming growth factor beta1 (TGF-beta1) and tissue inhibitor of metalloproteinase 1 (TIMP-1). |
3(0,0,0,3) | Details |
| 18996463 | Mu Y, Liu P, Du G, Du J, Wang G, Long A, Wang L, Li F: Action mechanism of Yi Guan Jian Decoction on CCl4 induced cirrhosis in rats. J Ethnopharmacol. 2009 Jan 12;121(1):35-42. Epub 2008 Oct 18. At 12th weekend, the rats were sacrificed for sampling and detection of liver function, histological changes of liver tissue, liver tissue content and expression of alpha-SMA, CD68, MMP-13, TIMP-1, TIMP-2, Caspase-12, HGFalpha, MMP-2, MMP-9 and hepatocyte apoptotic index. |
3(0,0,0,3) | Details |
| 20358000 | Park SY, Shin HW, Lee KB, Lee MJ, Jang JJ: Differential expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in thioacetamide-induced chronic liver injury. J Korean Med Sci. 2010 Apr;25(4):570-6. Epub 2010 Mar 19. The MMP-TIMP balance can regulate liver fibrogenesis. |
2(0,0,0,2) | Details |
| 20159698 | He Y, Chen BL, Yang RP, Ren M, Zeng ZR: [Comparison of the pathogenesis of liver fibrosis induced by pig serum exposure and bile duct ligation in rats.]. Nan Fang Yi Ke Da Xue Xue Bao. 2010 Feb;30(2):270-4. Quantitative real time PCR (qPCR) analysis was employed to quantify the mRNA expression of the genes related to inflammation, including interleukin-1beta (IL-1beta), IL-6, monocyte chemotactic protein-1, tumor necrosis factor-alpha, regulated upon activation normal T cell expressed and secreted (RANTES), transforming growth factor-beta, platelet-derived growth factor A, as well as the genes associated with fibrogenesis, namely collagen 1, alphaSMA, MMP-9 and TIMP-1. |
2(0,0,0,2) | Details |
| 19114984 | Liu Y, Lui EL, Friedman SL, Li L, Ye T, Chen Y, Poon RT, Wo J, Kok TW, Fan ST: PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling. Lab Invest. 2009 Feb;89(2):209-21. Epub 2008 Dec 29. In primary HSCs, PTK/ZK inhibited the expression of alpha-smooth muscle actin (alpha-SMA), collagen, tissue inhibitor of metalloproteinase-1 (TIMP-1), as well as cell proliferation, migration and actin filament formation. |
2(0,0,0,2) | Details |
| 19517234 | Nie QH, Zhu CL, Zhang YF, Yang J, Zhang JC, Gao RT: Inhibitory Effect of Antisense Oligonucleotide Targeting TIMP-2 on Immune-Induced Liver Fibrosis. Dig Dis Sci. 2009 Jun 11. INTRODUCTION: We previously reported that both experimental and human studies have shown the importance of TIMP-1 and TIMP-2 in the development of liver fibrosis, a disease mostly caused by HBV and HCV infection in China. |
2(0,0,0,2) | Details |
| 19410625 | Tao FF, Yang YF, Wang H, Sun XJ, Luo J, Zhu X, Liu F, Wang Y, Su C, Wu HW, Zhang ZS: Th1-type epitopes-based cocktail PDDV attenuates hepatic fibrosis in C57BL/6 mice with chronic Schistosoma japonicum infection. Vaccine. 2009 Jun 24;27(31):4110-7. Epub 2009 May 15. The histopathological staging and collagen assessment for fibrosis showed that the cocktail PDDV presented an obvious down-regulation effect on hepatic fibrosis caused by chronic S. japonicum infection (P <0.05), and IFN-gamma, IL-4 and IL-13 mRNAs in liver detected by RT-PCR also showed that the cocktail PDDV represented the ability to up-regulate Th1-type responses, which paralleled with a decrease expression of alpha-SMA (P <0.05) and the up-regulated MMP9/TIMP1 balance (P <0.05) when compared to the control groups. |
2(0,0,0,2) | Details |
| 20038332 | Wu XR, Wang Q, Wang L, Shi SS, Guo WD: [The effect of urokinase on hepatic fibrogenesis in rats] . Zhonghua Gan Zang Bing Za Zhi. 2009 Dec;17(12):910-4. The expression of alpha-SMA, uPA, PAI-1, TGFb1, TIMP-1, collagen type I and type III proteins in hepatic fibrosis tissue was detected by immunohistochemistry, the expression of PAI-1 and TGFb1 mRNA in the hepatic fibrosis tissue was quantified by real time RT-PCR. |
2(0,0,0,2) | Details |
| 19224893 | Wang Z, Chen C, Finger SN, Kwajah S, Jung M, Schwarz H, Swanson N, Lareu FF, Raghunath M: Suberoylanilide hydroxamic acid: a potential epigenetic therapeutic agent for lung fibrosis?. Eur Respir J. 2009 Jul;34(1):145-55. Collagen deposition, alpha-smooth muscle actin (alpha-SMA) expression, matrix metalloproteinase (MMP) 1 activity, tissue inhibitor of MMP (TIMP) 1 production, apoptosis and cell proliferation were assessed. |
2(0,0,0,2) | Details |
| 19207580 | Bechmann LP, Zahn D, Gieseler RK, Fingas CD, Marquitan G, Jochum C, Gerken G, Friedman SL, Canbay A: amplifies profibrogenic effects of free fatty acids on human hepatic stellate cells. Hepatol Res. 2009 Jun;39(6):601-8. Epub 2009 Jan 14. Results: Compared to vehicle controls, incubation of LX-2 cells with 0.5 mM FFAs induced profibrogenic genes (alpha-SMA x 2.9; TGF-beta1 x 1.6; TIMP-1 x 1.4), death receptors (CD95/Fas x 3.8; TNFR-1 x 1.4), and anti-apoptotic molecules (Bcl-2 x 2.3; Mcl-1 x 1.3). |
2(0,0,0,2) | Details |
| 17884089 | Wakisaka O, Takahashi N, Shinohara T, Ooie T, Nakagawa M, Yonemochi H, Hara M, Shimada T, Saikawa T, Yoshimatsu H: Hyperthermia treatment prevents angiotensin II-mediated atrial fibrosis and fibrillation via induction of heat-shock protein 72. J Mol Cell Cardiol. 2007 Nov;43(5):616-26. Epub 2007 Aug 16. HT induced the expression of HSP72, which was associated with the attenuation of AII-induced extracellular signal-regulated kinase (ERK1/ERK2) phosphorylation, alpha-smooth muscle actin (alpha-SMA) expression, transforming growth factor-beta (1) secretion, collagen synthesis, and expression of collagen type I and tissue inhibitor of metalloproteinases-1. |
1(0,0,0,1) | Details |
| 18317806 | Maeda T, Hashitani S, Zushi Y, Segawa E, Tanaka N, Sakurai K, Urade M: Establishment of a nude mouse transplantable model of a human malignant fibrous histiocytoma of the mandible with high metastatic potential to the lung. J Cancer Res Clin Oncol. 2008 Sep;134(9):1005-11. Epub 2008 Mar 4. In MFH-NC, the expressions of MMP7, MMP9, MT1-MMP, CXCR4, COX-2 and integrin alpha4 were up-regulated, while those of MMP2 and TIMP1 were down-regulated. |
1(0,0,0,1) | Details |
| 19376089 | Szuster-Ciesielska A, Plewka K, Daniluk J, Kandefer-Szerszen M: supplementation attenuates - and -induced liver stellate cell activation by inhibiting reactive species (ROS) production and by influencing intracellular signaling. Biochem Pharmacol. 2009 Aug 1;78(3):301-14. Epub 2009 Apr 17. down-regulated - and -induced production of TIMP-1 and TIMP-2 and decreased the activity of MMP-2. |
1(0,0,0,1) | Details |
| 20034937 | Schweitzer M, Mitmaker B, Obrand D, Sheiner N, Abraham C, Dostanic S, Meilleur M, Sugahara T, Chalifour LE: modulates matrix metalloproteinase expression, activity, and signaling in abdominal aortic aneurysms. Vasc Endovascular Surg. 2010 Feb;44(2):116-22. Epub 2009 Dec 23. Matrix metalloproteinase 1, MMP2, MMP3, MMP9, Tissue Inhibitor of Metalloproteinase (TIMP2), TIMP3, TIMP4, or total Sma Mothers Against Decapentaplegia (SMAD2) expression did not differ with treatment. There was a trend toward reduced MMP8 and TIMP1 expression and MMP2 zymographic activity in the AT-treatment group. |
1(0,0,0,1) | Details |
| 18996092 | Ishigaki N, Yamamoto N, Jin H, Uchida K, Terai S, Sakaida I: Continuos intravenous infusion of atrial natriuretic peptide (ANP) prevented liver fibrosis in rat. Biochem Biophys Res Commun. 2009 Jan 16;378(3):354-9. Epub 2008 Nov 6. In vitro, ANP suppressed alpha-SMA expression and was inhibited the growth of HSC, and reduced the expression of type 1 procollagen, TIMP-1, -2 expression. |
2(0,0,0,2) | Details |
| 18328066 | Maeda K, Koda M, Matono T, Sugihara T, Yamamoto S, Ueki M, Murawaki Y, Yamashita N, Nishiyama S: Preventive effects of ME3738 on hepatic fibrosis induced by bile duct ligation in rats. Hepatol Res. 2008 Jul;38(7):727-35. Epub 2008 Mar 4. The gene expressions of collagen-I, transforming growth factor-beta1 (TGF-beta1), tissue inhibitor of metalloproteinases-1 (TIMP-1), interleukin-6 (IL-6) and heme oxygenase-1 (HO-1) in the liver were examined by real-time reverse transcriptase polymerase chain reaction (RT-PCR). |
2(0,0,0,2) | Details |
| 20177740 | Deng B, Yang X, Liu J, He F, Zhu Z, Zhang C: Focal adhesion kinase mediates TGF-beta1-induced renal tubular epithelial-to-mesenchymal transition in vitro. Mol Cell Biochem. 2010 Feb 23. The expression of FAK, alpha-smooth muscle actin (alpha-SMA),E-cadherin, Akt, matrix metallopeptidase-9 (MMP-9),tissue inhibitor of metalloproteinase-1 (TIMP-1), and collagen IV were detected by RT-PCR, Western blot and immunofluorescence methods, respectively. |
2(0,0,0,2) | Details |
| 18939363 | Garncarczyk A, Jurzak M, Gojniczek K: [Characteristic of the endogenous peptides--endothelins and their role in the connective tissue fibrosis]. Wiad Lek. 2008;61(4-6):126-34. The dual regulatory role of ET-1 consist on stimulation of collagen I and III synthesis and simultaneously on inhibition of MMP-1 expression through inhibition of tissue inhibitors of metalloproteinase: TIMP-1 and TIMP-3. |
1(0,0,0,1) | Details |
| 19934446 | Kurata K, Maruyama S, Kato S, Sato W, Yamamoto J, Ozaki T, Nitta A, Nabeshima T, Morita Y, Mizuno M, Ito Y, Yuzawa Y, Matsuo S: Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice. Am J Physiol Renal Physiol. 2009 Dec;297(6):F1510-7. Protein levels of MMP-3, tissue inhibitor of metalloproteinases (TIMP)-1, -2, and -3, phospho-Smad3, membrane-type 1 (MT1)-MMP, and MT3-MMP were also studied. |
1(0,0,0,1) | Details |
| 18490073 | Schwettmann L, Wehmeier M, Jokovic D, Aleksandrova K, Brand K, Manns MP, Lichtinghagen R, Bahr MJ: Hepatic expression of A disintegrin and metalloproteinase (ADAM) and ADAMs with thrombospondin motives (ADAM-TS) enzymes in patients with chronic liver diseases. J Hepatol. 2008 Aug;49(2):243-50. Epub 2008 Apr 24. METHODS: Seventy-one biopsy samples from patients with chronic liver diseases were analyzed for mRNA expression of ADAM-8, -9, -12, -28, -TS1, -TS2, matrix metalloprotease (MMP)-2, -9 and tissue inhibitor of metalloproteinases-1 and -2 by quantitative real-time RT-PCR. |
1(0,0,0,1) | Details |
| 19192169 | Li YL, Wu J, Wei D, Zhang DW, Feng H, Chen ZN, Bian H: Newcastle disease virus represses the activation of human hepatic stellate cells and reverses the development of hepatic fibrosis in mice. Liver Int. 2009 Apr;29(4):593-602. Epub 2009 Jan 28. RESULTS: Tumour-CM and transforming growth factor-beta1 (TGF-beta1) could promote the proliferation and activation of LX-2 cells, indicated by the enhanced expression of alpha-SMA, collagen I, tissue inhibitor of metalloproteinase (TIMP)-1 and TGF-beta1. |
1(0,0,0,1) | Details |
| 20092986 | Kobayashi H, Tanaka Y, Asagiri K, Asakawa T, Tanikawa K, Kage M, Yagi M: The antioxidant effect of green ameliorates experimental liver injury. Phytomedicine. 2010 Mar;17(3-4):197-202. Epub 2010 Jan 25. We also evaluated the levels of activator protein-1 m-RNA (AP-1 m-RNA) and tissue inhibitor metalloproteinase-1 m-RNA (TIMP-1 m-RNA) by Real Time PCR. |
1(0,0,0,1) | Details |
| 19342509 | Gieling RG, Wallace K, Han YP: Interleukin-1 participates in the progression from liver injury to fibrosis. Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1324-31. Epub 2009 Apr 2. In the early phase of liver injury, the MMP-9, MMP-13, and TIMP-1 expression correlated well with IL-1 levels. |
1(0,0,0,1) | Details |
| 20062961 | Vercelino R, Crespo I, de Souza GF, Cuevas MJ, de Oliveira MG, Marroni NP, Gonzalez-Gallego J, Tunon MJ: S-nitroso- attenuates liver fibrosis in cirrhotic rats. J Mol Med. 2010 Apr;88(4):401-11. Epub 2010 Jan 9. SNAC down-regulated expression of collagen 1 alpha, alpha-SMA, tumor necrosis factor-alpha, tumor growth factor-beta, metalloproteinase-2, metalloproteinase inhibitor 1, platelet-derived growth factor (PDGF), and PDGF receptor in CBDL rats. |
1(0,0,0,1) | Details |
| 17922224 | Wu LM, Wu XX, Sun Y, Kong XW, Zhang YH, Xu Q: A novel synthetic oleanolic acid derivative (CPU-II2) attenuates liver fibrosis in mice through regulating the function of hepatic stellate cells. J Biomed Sci. 2008 Mar;15(2):251-9. Epub 2007 Oct 6. CPU-II2 also attenuated the mRNA expression of alpha-smooth muscle actin (alpha-SMA) and tissue inhibitor of metalloproteinase type 1 (TIMP-1) induced by CCl4 in mice and reduced both mRNA and protein levels of alpha-SMA in HSC-T6 cells. |
1(0,0,0,1) | Details |
| 20208363 | Lim CS, Kim EY, Lee HS, Soh Y, Sohn Y, Kim SY, Sohn NW, Jung HS, Kim YB: Protective effects of Cinnamomum cassia Blume in the fibrogenesis of activated HSC-T6 cells and dimethylnitrosamine-induced acute liver injury in SD rats. Biosci Biotechnol Biochem. 2010 Mar 23;74(3):477-83. Epub 2010 Mar 7. CCE significantly reduced the expression of alpha-smooth muscle actin (alpha-SMA), connective tissue growth factor (CTGF), transforming growth factor beta (TGF-beta1), and tissue inhibitor of metalloproteinase-1 (TIMP-1). |
1(0,0,0,1) | Details |
| 18578993 | Liu HY, Yang Q, Duan RX, Zhang YW, Tang WX: [Effects of on the activation and proliferation of hepatic stellate cells through cannabinoid-2 receptors]. Zhonghua Gan Zang Bing Za Zhi. 2008 Jun;16(6):430-4. The expressions of alpha-SMA, TGFb1, a1 (I), a1 (III) and TIMP-1 were significantly suppressed by 20micromol/L AEA, but CBR2 antagonist AM630 reversed this suppressor action of AEA. |
1(0,0,0,1) | Details |
| 19723340 | Weng TC, Shen CC, Chiu YT, Lin YL, Kuo CD, Huang YT: Inhibitory effects of armepavine against hepatic fibrosis in rats. J Biomed Sci. 2009 Sep 2;16:78. Moreover, Arm attenuated the mRNA expression levels of col 1alpha2, TGF-beta1, TIMP-1, ICAM-1, iNOS, and IL-6 genes, but up-regulated metallothionein genes. |
1(0,0,0,1) | Details |
| 19388665 | Cheng K, Yang N, Mahato RI: TGF-beta1 gene silencing for treating liver fibrosis. . Mol Pharm. 2009 May-Jun;6(3):772-9. There was significant decrease in TGF-beta1 and TIMP-1 when HSC-T6 cells were transfected with pshRNA targeting the same regions of TGF-beta1 mRNA as siRNAs. |
1(0,0,0,1) | Details |