Protein Information

Name cytokeratin 18
Synonyms CK 18; CYK18; Cytokeratin 18; K18; KRT18; Keratin 18; Keratin 18 type I cytoskeletal; Cytokeratin 18s…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
20015471 Wang QL, Yuan JL, Tao YY, Zhang Y, Liu P, Liu CH: Fuzheng Huayu recipe and vitamin E reverse renal interstitial fibrosis through counteracting TGF-beta1-induced epithelial-to-mesenchymal transition. J Ethnopharmacol. 2010 Feb 17;127(3):631-40. Epub 2009 Dec 16.


Protein expression and the location of Smad3 in kidney was assayed by immunohistochemistry, E-cadherin, cytokeratin 18 (CK-18), alpha-SMA and TGF-beta1 by immunofluorescent stain.
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19054657 Ciba P, Sturmheit TM, Petschnik AE, Kruse C, Danner S: In vitro cultures of human pancreatic stem cells: gene and protein expression of designated markers varies with passage. Ann Anat. 2009 Jan;191(1):94-103. Epub 2008 Sep 20.


In particular, the course of spontaneous mRNA and protein expression of the genes for alpha-smooth muscle actin (alpha-SMA), neurofilaments (NF), cytokeratin 18 (CK18) and nestin was examined during 11 passages by means of RT-PCR and immunocytochemistry.
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18702012 Wang Y, Zhang Z, Shen H, Lu Y, Li H, Ren X, Wu G: TGF-beta1/Smad7 signaling stimulates renal tubulointerstitial fibrosis induced by AAI. J Recept Signal Transduct Res. 2008;28(4):413-28.


This was also immediately identified by the increased expression of vimentin and de novo expression of alpha-smooth muscle actin (alpha-SMA) with the loss of cytokeratin 18 (CK18) by semiquantitative reverse transcriptase-PCR (RT-PCR) and immunofluorescence staining.
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19640259 Li J, Zhang Z, Wang D, Wang Y, Li Y, Wu G: TGF-beta 1/Smads signaling stimulates renal interstitial fibrosis in experimental AAN. J Recept Signal Transduct Res. 2009;29(5):280-5.


Immunohistochemistry and semi-quantitative reverse transcriptase (RT-PCR) detection of the increased expression of fibroblast marker vimentin and de novo expression of alpha-smooth muscle actin (alpha-SMA) with the loss of epithelial maker cytokeratin 18 (CK18) can be utilized to assess AAI-induced tubular necrosis and extensive cortical interstitial fibrosis in a dose-dependent manner.
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