Protein Information

Name Bcl x
Synonyms Apoptosis regulator Bcl X; BCL XL/S; BCL2 like 1; BCL2 related gene; BCL2 like 1 isoform 1; BCL2L; BCL2L1; BCLX…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18590823 Tsai LK, Tsai MS, Ting CH, Wang SH, Li H: Restoring Bcl-x (L) levels benefits a mouse model of spinal muscular atrophy. Neurobiol Dis. 2008 Sep;31(3):361-7. Epub 2008 Jun 3.

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19525895 Martinez-Hernandez R, Soler-Botija C, Also E, Alias L, Caselles L, Gich I, Bernal S, Tizzano EF: The developmental pattern of myotubes in spinal muscular atrophy indicates prenatal delay of muscle maturation. J Neuropathol Exp Neurol. 2009 May;68(5):474-81.


Here, we performed histological and morphometric analysis of myotubes and assessed DNA fragmentation and Bcl-2/Bcl-X (L) expression in skeletal muscle from fetuses with type I SMA (at approximately 12 and 15 weeks' gestational ages, n = 4) and controls (at approximately 10-15 weeks' gestational ages, n = 7).
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18649067 Tsai LK, Tsai MS, Ting CH, Li H: Multiple therapeutic effects of valproic acid in spinal muscular atrophy model mice. J Mol Med. 2008 Nov;86(11):1243-54. Epub 2008 Jul 23.


VPA also increased levels of anti-apoptotic factors, Bcl-2 and Bcl-x (L), in spinal neurons.
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