| Name | integrin linked kinase |
|---|---|
| Synonyms | 59 kDa serine/threonine protein kinase; ILK; ILK protein; ILK 1; ILK 2; ILK1; ILK2; Integrin linked protein kinase 1… |
| Name | SMA |
|---|---|
| CAS | sodium 2-chloroacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18550647 | Ardura JA, Berruguete R, Ramila D, Alvarez-Arroyo MV, Esbrit P: Parathyroid hormone-related protein interacts with vascular endothelial growth factor to promote fibrogenesis in the obstructed mouse kidney. Am J Physiol Renal Physiol. 2008 Aug;295(2):F415-25. Epub 2008 Jun 11. These changes were associated with higher fibronectin mRNA expression and alpha-smooth muscle actin (alpha-SMA) and integrin-linked kinase (ILK) immunostaining and lower apoptotic tubulointerstitial cells in the mouse obstructed kidney than in control littermates. |
1(0,0,0,1) | Details |
| 19460706 | He F, Yu L, Tong JR, Luo ZM, Zhu QZ, Wang Y, Zhang JL: [Role of integrin-linked kinase in renal tubular epithelial-mesenchymal transition and the regulatory effect of urokinae on its expression in mice with obstructive nephropathy]. Nan Fang Yi Ke Da Xue Xue Bao. 2009 May;29(5):909-13. |
2(0,0,0,2) | Details |
| 19134459 | Chen TF, Chen M, Qin JH, Wang MY: [Interventional effects of emodin on transforming growth factor-beta1/integrin-linked kinase signal way in interleukin-1beta-induced transdifferentiation of rat tubular epithelial-myofibroblasts]. Zhong Xi Yi Jie He Xue Bao. 2009 Jan;7(1):59-64. |
2(0,0,0,2) | Details |
| 18037995 | Hu K, Wu C, Mars WM, Liu Y: Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling. J Clin Invest. 2007 Dec;117(12):3821-32. Furthermore, inhibition of the integrin-linked kinase (ILK), a downstream effector of beta1 integrin, or disruption of beta1 integrin/ILK engagement, abrogated the tPA action, whereas ectopic expression of ILK mimicked tPA in promoting myofibroblast activation. |
1(0,0,0,1) | Details |
| 18538087 | Chen TF, Chen M, Qin JH, Wang MY: [Interventional effect of emodin on the expression of intergern linked kinase in tubular epithelial-myofibroblast transdifferentiation]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Jun;24(6):574-6. The expression of a-smooth muscle actin (a-SMA) and E-cadherin were detected using a two-color immunohistochemistry staining technique, while the expression of integrin-linked kinase (ILK) was detected using a one-color immunohistochemistry staining technique. |
1(0,0,0,1) | Details |
| 19915584 | Zheng YP, Liu H, Zeng H, Xiong L, Feng ZH, Sun NX: Downregulation of lentivirus-mediated ILK RNAi on tractional force generation in human retinal Muller cells. Acta Pharmacol Sin. 2009 Dec;30(12):1625-33. Epub 2009 Nov 16. AIM: To investigate the effect of lentivirus-mediated integrin-linked kinase (ILK) RNA interference (RNAi) on human retinal Muller cells transdifferentiation into contractile myofibroblasts. |
1(0,0,0,1) | Details |
| 17951996 | Liu BC, Li MX, Zhang JD, Liu XC, Zhang XL, Phillips AO: Inhibition of integrin-linked kinase via a siRNA expression plasmid attenuates connective tissue growth factor-induced human proximal tubular epithelial cells to mesenchymal transition. Am J Nephrol. 2008;28(1):143-51. Epub 2007 Oct 19. |
1(0,0,0,1) | Details |