Protein Information

Name nestin
Synonyms NES; Nbla00170; Nestin; Nbla00170s; Nestins

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19271685 Mokry J, Ehrmann J, Karbanova J, Cizkova D, Soukup T, Suchanek J, Filip S, Kolar Z: Expression of intermediate filament nestin in blood vessels of neural and non-neural tissues. Acta Medica (Hradec Kralove). 2008;51(3):173-9.

8(0,0,0,8) Details
18005096 Moreels M, Vandenabeele F, Dumont D, Robben J, Lambrichts I: Alpha-smooth muscle actin (alpha-SMA) and nestin expression in reactive astrocytes in multiple sclerosis lesions: potential regulatory role of transforming growth factor-beta 1 (TGF-beta1). Neuropathol Appl Neurobiol. 2008 Oct;34(5):532-46. Epub 2007 Nov 14.

7(0,0,0,7) Details
19552766 Rogelsperger O, Ekmekcioglu C, Jager W, Klimpfinger M, Konigsberg R, Krenbek D, Sellner F, Thalhammer T: Coexpression of the melatonin receptor 1 and nestin in human breast cancer specimens. J Pineal Res. 2009 May;46(4):422-32. Epub 2009 Mar 30.

5(0,0,0,5) Details
19642511 Weiss S, Siebzehnrubl FA, Kreutzer J, Blumcke I, Buslei R: Evidence for a progenitor cell population in the human pituitary. . Clin Neuropathol. 2009 Jul-Aug;28(4):309-18.


In tissue sections of the anterior lobe nestin immunoreactive cells co-expressing smooth muscle actin (SMA) were identified in the perivascular space, indicating a pericytic differentiation.
2(0,0,0,2) Details
20126464 Lermen D, Gorjup E, Dyce PW, von Briesen H, Muller P: Neuro-muscular differentiation of adult porcine skin derived stem cell-like cells. PLoS One. 2010 Jan 29;5(1):e8968.


Furthermore, the expression of the progenitor marker nestin, the somatic stem cell markers Bcrp1/ABCG2, Bmi1, and Stat3 was detected by reverse transcriptase-polymerase chain reaction (RT-PCR) in undifferentiated pSSCs.
2(0,0,0,2) Details
19816704 Karaoz E, Dogan BN, Aksoy A, Gacar G, Akyuz S, Ayhan S, Genc ZS, Yuruker S, Duruksu G, Demircan PC, Sariboyaci AE: Isolation and in vitro characterisation of dental pulp stem cells from natal teeth. Histochem Cell Biol. 2010 Jan;133(1):95-112. Epub 2009 Oct 9.


Ultrastructural characteristics of hNDP-SCs showed more developed and metabolically active cells. hNDP-SCs and hBM-MSCs expressed some adipogenic (leptin, adipophilin and PPARgamma), myogenic (desmin, myogenin, myosinIIa, and alpha-SMA), neurogenic (gamma-enolase, MAP2a,b, c-fos, nestin, NF-H, NF-L, GFAP and betaIII tubulin), osteogenic (osteonectin, osteocalcin, osteopontin, Runx-2, and type I collagen) and chondrogenic (type II collagen, SOX9) markers without any stimulation towards differentiation under basal conditions.
1(0,0,0,1) Details
19054657 Ciba P, Sturmheit TM, Petschnik AE, Kruse C, Danner S: In vitro cultures of human pancreatic stem cells: gene and protein expression of designated markers varies with passage. Ann Anat. 2009 Jan;191(1):94-103. Epub 2008 Sep 20.


In particular, the course of spontaneous mRNA and protein expression of the genes for alpha-smooth muscle actin (alpha-SMA), neurofilaments (NF), cytokeratin 18 (CK18) and nestin was examined during 11 passages by means of RT-PCR and immunocytochemistry.
1(0,0,0,1) Details
19688349 Karaoz E, Aksoy A, Ayhan S, Sariboyaci AE, Kaymaz F, Kasap M: Characterization of mesenchymal stem cells from rat bone marrow: ultrastructural properties, differentiation potential and immunophenotypic markers. Histochem Cell Biol. 2009 Nov;132(5):533-46. Epub 2009 Aug 14.


Immunohistochemistry and RT-PCR results indicated that BM-MSCs expressed myogenic (desmin, myogenin, myosin IIa, and alpha-SMA), neurogenic (gamma-enolase, MAP2a,b, c-fos, nestin, GFAP and beta III tubulin), and osteogenic (osteonectin, osteocalcin, osteopontin, Runx-2, BMP-2, BMP-4 and type I collagen) markers without stimulation towards differentiation.
1(0,0,0,1) Details
19910699 Barreira AL, Takiya CM, Castiglione RC, Maron-Gutierrez T, Barbosa CM, Ornellas DS, Verdoorn KS, Pascarelli BM, Borojevic R, Einicker-Lamas M, Leite M Jr, Morales MM, Vieyra A: Bone marrow mononuclear cells attenuate interstitial fibrosis and stimulate the repair of tubular epithelial cells after unilateral ureteral obstruction. Cell Physiol Biochem. 2009;24(5-6):585-94. Epub 2009 Nov 4.


Simultaneously, nestin+ cells increased in the interstitium and decreased in the tubules.
1(0,0,0,1) Details
18154518 Kim J, Kang HM, Kim H, Kim MR, Kwon HC, Gye MC, Kang SG, Yang HS, You J: Ex vivo characteristics of human amniotic membrane-derived stem cells. . Cloning Stem Cells. 2007 Winter;9(4):581-94.


RT-PCR analysis showed that all four HAM cell lines consistently expressed genes of Oct-4, Rex-1, SCF, NCAM, nestin, BMP-4, GATA-4, HNF-4alpha, vimentin, and CK18, regardless of the passage number.
1(0,0,0,1) Details
20185896 Griesche N, Luttmann W, Luttmann A, Stammermann T, Geiger H, Baer PC: A Simple Modification of the Separation Method Reduces Heterogeneity of Adipose-Derived Stem Cells. Cells Tissues Organs. 2010 Feb 24.


Washing led to a significantly lower expression of desmin, smA and six2, and a higher expression of the stem cell markers nestin, oct-4 and sall-1, compared to standard isolated cells, while the immunomagnetically isolated cells showed no significant changes.
0(0,0,0,0) Details