Protein Information

Name cyclin E
Synonyms CCNE; CCNE 1; CCNE1; Cyclin E; Cyclin E1; Cyclin Es; Cyclin Et; G1/S specific cyclin E1…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
20193347 Hu JM, Zhong NS: [A preliminary study on the mechanisms of N-acetylcysteine in the inhibition of proliferation and collagen synthesis of human pulmonary fibroblasts.]. Zhonghua Jie He He Hu Xi Za Zhi. 2009 Dec;32(12):897-901.


Proteins of cyclin E, alpha-SMA and STAT-3 were detected with Western blotting.
4(0,0,0,4) Details
19114984 Liu Y, Lui EL, Friedman SL, Li L, Ye T, Chen Y, Poon RT, Wo J, Kok TW, Fan ST: PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling. Lab Invest. 2009 Feb;89(2):209-21. Epub 2008 Dec 29.


PTK/ZK also induced cell cycle arrest, accompanied by increasing the expression of p27 (Kip1) and downregulation of cyclin D1 and cyclin E.
1(0,0,0,1) Details
19329552 Schuliga MJ, See I, Ong SC, Soon L, Camoretti-Mercado B, Harris T, Stewart AG: Fibrillar collagen clamps lung mesenchymal cells in a nonproliferative and noncontractile phenotype. Am J Respir Cell Mol Biol. 2009 Dec;41(6):731-41. Epub 2009 Mar 27.


DNA profiles indicated that fCollagen is antiproliferative, rather than proapoptotic. fCollagen suppressed basic fibroblast growth factor-stimulated increases in the levels of cyclin E and CDK2 mRNA. fCollagen also suppressed transforming growth factor-beta (100 pM)-stimulated increases in the mRNA and protein levels of alpha-smooth muscle actin (alpha-SMA), a marker of the myofibroblast phenotype.
1(0,0,0,1) Details