Protein Information

Name chondroitin sulfate proteoglycan NG2
Synonyms CSPG 4; NG2; MCSP; MSK16; CSPG4; Chondroitin sulfate proteoglycan 4; Chondroitin sulfate proteoglycan 4 precursor; Chondroitin sulfate proteoglycan NG2…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
19014648 Kapoor M, Liu S, Huh K, Parapuram S, Kennedy L, Leask A: Connective tissue growth factor promoter activity in normal and wounded skin. Fibrogenesis Tissue Repair. 2008 Oct 13;1(1):3.


Unwounded (day 0) and wounded (days 3 and 7) skin was examined for GFP to detect cells in which the CTGF promoter was active, alpha-smooth muscle actin (alpha-SMA) to detect myofibroblasts, and NG2 expression to detect pericytes.
2(0,0,0,2) Details
19916059 Liu S, Taghavi R, Leask A: Connective tissue growth factor is induced in bleomycin-induced skin scleroderma. J Cell Commun Signal. 2009 Nov 15.


Control (PBS injected) and fibrotic (bleomycin-injected) dermis was examined for CCN2, alpha-smooth muscle actin (alpha-SMA) (to detect myofibroblasts), and NG2 (to detect pericytes) expression.
2(0,0,0,2) Details
18602987 Norsted E, Gomuc B, Meister B: Protein components of the blood-brain barrier (BBB) in the mediobasal hypothalamus. J Chem Neuroanat. 2008 Oct;36(2):107-21. Epub 2008 Jun 18.


In order to clarify the nature of the BBB in the median eminence-arcuate nucleus complex, we have used immunohistochemistry and antisera to protein components of the BBB-(1) tight junctions, claudin-5 and zona occludens-1 (ZO-1); (2) endothelial cells: (a) all endothelial cells: rat endothelial cell antigen-1 (RECA-1), (b) endothelial cells at BBB: endothelial barrier antigen (EBA), glucose transporter 1 (GLUT1) and transferrin receptor (TfR), and (c) endothelial cells at CVOs: dysferlin; (3) basal lamina: laminin; (4) vascular smooth muscle cells: smooth muscle actin (SMA); (5) pericytes: chondroitin sulfate proteoglycan (NG2); (6) glial cells: (a) astrocytes: glial fibrillary acidic protein (GFAP), (b) tanycytes: dopamine- and cAMP-regulated phosphoprotein of 32kDA (DARPP-32), (c) microglia: CD11b.
1(0,0,0,1) Details
19146948 Maolood N, Meister B: Protein components of the blood-brain barrier (BBB) in the brainstem area postrema-nucleus tractus solitarius region. J Chem Neuroanat. 2009 May;37(3):182-95. Epub 2008 Dec 25.


To clarify the cellular localization of protein components of the BBB in the brainstem AP-NTS region, we used antisera to--(1) Tight junctions: claudin-5 and zona occludens-1 (ZO-1). (2) Endothelial cells: (a) all endothelial cells--rat endothelial cell antigen-1 (RECA-1) and (b) endothelial cells at BBB--endothelial barrier antigen (EBA), glucose transporter 1 (GLUT1) and transferrin receptor (TfR). (3) Basal lamina--laminin. (4) Vascular smooth muscle cells--smooth muscle actin (SMA). (5) Pericytes--chondroitin sulfate proteoglycan (NG2). (6) Glial cells: (a) astrocytes--glial fibrillary acidic protein (GFAP), (b) tanycytes--dopamine- and cAMP-regulated phosphoprotein of 32 kDA (DARPP-32), and (c) microglia--CD11b.
1(0,0,0,1) Details
18240955 Bababeygy SR, Cheshier SH, Hou LC, Higgins DM, Weissman IL, Tse VC: Hematopoietic stem cell-derived pericytic cells in brain tumor angio-architecture. Stem Cells Dev. 2008 Feb;17(1):11-8.


LT-HSC-derived GFP+ cells express the pericyte progenitor marker, platelet-derived growth factor receptor-beta (PDGFR beta), as well as mature perictyte markers such as nerve/glial antigen 2 proteoglycan (NG2), alpha-smooth muscle actin (alpha SMA), and desmin.
1(0,0,0,1) Details
20103680 Schadler KL, Zweidler-McKay PA, Guan H, Kleinerman ES: Delta-like ligand 4 plays a critical role in pericyte/vascular smooth muscle cell formation during vasculogenesis and tumor vessel expansion in Ewing's sarcoma. Clin Cancer Res. 2010 Feb 1;16(3):848-56. Epub 2010 Jan 26.


Inhibition of DLL4 expression by short hairpin RNA correlated with the decreased numbers of BM-derived cells in tumor vessels and the decreased numbers of alpha-SMA (+), desmin (+), and NG2 (+) pericytes/vSMCs, as well as increased tumor hypoxia.
1(0,0,0,1) Details
19264887 Baba T, Grebe R, Hasegawa T, Bhutto I, Merges C, McLeod DS, Lutty GA: Maturation of the fetal human choriocapillaris. Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3503-11. Epub 2009 Mar 5.


METHODS: Immunohistochemistry was performed on cryopreserved sections of embryonic/fetal human eyes from 7 to 22 weeks' gestation (WG), using antibodies against PAL-E, PV-1 (fenestrations), carbonic anhydrase IV (CA IV), eNOS, and alpha-smooth muscle actin (alphaSMA) and NG2 (two pericyte markers) and the EC marker (CD31).
1(0,0,0,1) Details
19086261 Shi X, Han W, Yamamoto H, Tang W, Lin X, Xiu R, Trune DR, Nuttall AL: The cochlear pericytes. Microcirculation. 2008 Aug;15(6):515-29.


MATERIALS AND METHODS: Cochlear pericytes were identified by the immunofluorescence labeling of pericyte marker proteins, including alpha-smooth muscle actin (alpha-SMA), desmin, Thy-1, tropomyosin, and NG2, and by morphological identification, using fluorescence, electron, and differential interference contrast microscopy.
1(0,0,0,1) Details
18608982 Shi X, Han W, Yamamoto H, Tang W, Lin X, Xiu R, Trune DR, Nuttall AL: The Cochlear Pericytes. Microcirculation. 2008 Jul 1:1.


Materials and Methods: Cochlear pericytes were identified by the immunofluorescence labeling of pericyte marker proteins, including alpha-smooth muscle actin (alpha-SMA), desmin, Thy-1, tropomyosin, and NG2, and by morphological identification, using fluorescence, electron, and differential interference contrast microscopy.
1(0,0,0,1) Details